Tailoring the physicochemical and shape memory properties of the biodegradable polymer poly(glycerol dodecanoate) via curing conditions.
Tailoring the physicochemical and shape memory properties of the biodegradable polymer poly(glycerol dodecanoate) via curing conditions.
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DOI：
10.1002/jbm.a.35973
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Hollister SJ
中科院分区：
文献类型：
--
作者：
Solorio LD;Bocks ML;Hollister SJ
由于老化、损伤或疾病而发生的软组织损伤的修复和再生的主要挑战是再现天然组织的生物力学特性。理想地，用于软组织工程应用的候选生物材料应当是生物相容的、非线性弹性的以匹配软组织机械行为、可生物降解的以使得能够进行组织重塑，并且可定制的以实现一系列非线性弹性机械特性以匹配特定的软组织。此外，对于心脏和其他应用，生物材料应具有形状记忆特性，以促进微创和/或基于导管的递送。聚（十二酸甘油酯）（PGD）是一种形状记忆材料，在体温下具有非线性弹性，在室温下具有弹塑性行为。在这项研究中，我们研究了固化条件对PGD的非线性弹性，形状记忆和生物相容性的影响。固化和交联的增加导致PGD的初始刚度和非线性应变硬化行为的增加。在60%应变下形状固定后，对于所有测试条件，在体温下1分钟内实现100%形状恢复。聚合物固化对PGD的细胞生物相容性或非溶血特性没有不良影响，表明这些制剂对血液接触器械应用的潜在适用性。
A major challenge in the repair and regeneration of soft tissue damage occurring as a result of aging, injury, or disease is recapitulating the biomechanical properties of the native tissue. Ideally, a candidate biomaterial for soft tissue engineering applications should be biocompatible, nonlinearly elastic to match soft tissue mechanical behavior, biodegradable to enable tissue remodeling, and tailorable to achieve a range of nonlinear elastic mechanical properties to match specific soft tissues. In addition, for cardiac and other applications, the biomaterial should have shape memory characteristics to facilitate minimally invasive and/or catheter-based delivery. Poly(glycerol dodecanoate) (PGD) is a shape memory material that has nonlinear elastic properties at body temperature and elastic-plastic behavior at room temperature. In this study, we investigated the effects of curing conditions on the nonlinear elastic, shape memory, and biocompatibility properties of PGD. Increased curing and crosslinking resulted in an increase in both the initial stiffness and the nonlinear strain stiffening behavior of PGD. After shape fixation at 60% strain, 100% shape recovery was achieved within 1 minute at body temperature for all conditions tested. Polymer curing had no adverse effects on the cellular biocompatibility or non-hemolytic characteristics of PGD, indicating the potential suitability of these formulations for blood-contacting device applications.
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DOI：
10.1002/jbm.b.31568
发表时间：
2010-04
影响因子：
3.4
作者：
Jeong, Claire G.;Hollister, Scott J.
通讯作者：
Hollister, Scott J.
影响因子：
14
作者：
Migneco, Francesco;Huang, Yen-Chih;Birla, Ravi K.;Hollister, Scott J.
通讯作者：
Hollister, Scott J.
DOI：
10.1093/icb/24.1.13
发表时间：
1984-01-01
期刊：
AMERICAN ZOOLOGIST
影响因子：
--
作者：
FUNG, YC
通讯作者：
FUNG, YC
影响因子：
14
作者：
Motlagh, Delara;Yang, Jian;Ameer, Guillermo A.
通讯作者：
Ameer, Guillermo A.
影响因子：
4.5
作者：
Jaafar, Israd H.;Ammar, Mohamed M.;Coulter, John P.
通讯作者：
Coulter, John P.