Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol-co-citrate) scaffolds for soft tissue engineering.
Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol-co-citrate) scaffolds for soft tissue engineering.
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DOI：
10.1002/jbm.b.31568
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发表时间：
2010-04
影响因子：
3.4
通讯作者：
Hollister, Scott J.
中科院分区：
文献类型：
--
作者：
Jeong, Claire G.;Hollister, Scott J.
聚（1,8-辛二醇-共柠檬酸）（POC）是一种合成的可生物降解弹性体，可用于组织工程的三维支架。我们研究了设计孔隙率对POC支架的力学性能、渗透性和降解特性的影响。力学性能方面，支架压缩数据符合一维非线性弹性模型，实体拉伸数据符合Neohookean不可压缩非线性弹性模型。将软骨细胞植入支架，评估POC的生物相容性。孔隙度增加，降解率增加，渗透率增加，机械刚度降低，非线性减少。本文的支架表征将为POC支架的设计提供指导，以满足软骨等工程软组织所需的力学和生物学参数。
Poly(1,8-octanediol-co-citric acid) (POC) is a synthetic biodegradable elastomer that can be processed into 3D scaffolds for tissue engineering. We investigated the effect of designed porosity on the mechanical properties, permeability and degradation profiles of the POC scaffolds. For mechanical properties, scaffold compressive data was fit to a 1D nonlinear elastic model and solid tensile data was fit to a Neohookean incompressible nonlinear elastic model. Chondrocytes were seeded on scaffolds to assess the biocompatibility of POC. Increased porosity was associated with increased degradation rate, increased permeability, and decreased mechanical stiffness which also became less nonlinear. Scaffold characterization in this paper will provide design guidance for POC scaffolds to meet the mechanical and biological parameters needed for engineering soft tissues such as cartilage.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1016/j.bbrc.2003.09.099
发表时间：
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影响因子：
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作者：
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通讯作者：
Hollister, Scott