4D flow magnetic resonance imaging in bicuspid aortic valve disease demonstrates altered distribution of aortic blood flow helicity.
4D flow magnetic resonance imaging in bicuspid aortic valve disease demonstrates altered distribution of aortic blood flow helicity.
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DOI：
10.1002/mrm.24802
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发表时间：
2014-04
影响因子：
3.3
通讯作者：
Markl, M.
中科院分区：
文献类型：
--
作者：
Lorenz, R.;Bock, J.;Barker, A. J.;von Knobelsdorff-Brenkenhoff, F.;Wallis, W.;Korvink, J. G.;Bissell, M. M.;Schulz-Menger, J.;Markl, M.
主动脉几何形状的改变或主动脉瓣疾病的存在可导致主动脉血流动力学的实质性改变。升主动脉扩张或主动脉瓣异常可导致螺旋血流增加。利用沿整个主动脉等距分布的二维平面，采用4D血流MRI测试定量螺旋度分析的可行性。对该方法的评价包括三个部分：1)对12名健康受试者的螺旋度量化，2)对观察者变异性和重测信度的评估，3)对16例先天性双尖瓣改变患者的螺旋流量量化。健康受试者的螺旋度量化显示整个主动脉血流旋转方向一致，主动脉弓呈高顺时针螺旋度，升降主动脉呈相反旋转。结果显示了良好的扫描扫描和观察者之间和内部的螺旋参数的一致性。患者的螺旋度量化显示收缩期绝对峰值相对螺旋度显著增加，主动脉平均螺旋度分布明显不均匀。该方法有可能作为比较健康受试者和患者之间或不同患者组之间螺旋流的参考分布。
Changes in aortic geometry or presence of aortic valve disease can result in substantially altered aortic hemodynamics. Dilatation of the ascending aorta or aortic valve abnormalities can result in an increase in helical flow. 4D flow MRI was used to test the feasibility of quantitative helicity analysis using equidistantly distributed 2D planes along the entire aorta. The evaluation of the method included three parts: 1) the quantification of helicity in 12 healthy subjects, 2) an evaluation of observer variability and test-retest reliability, and 3) the quantification of helical flow in 16 patients with congenitally altered bicuspid aortic valves. Helicity quantification in healthy subjects revealed consistent directions of flow rotation along the entire aorta with high clockwise helicity in the aortic arch and an opposite rotation sense in the ascending and descending aorta. The results demonstrated good scan-rescan and inter- and intra-observer agreement of the helicity parameters. Helicity quantification in patients revealed a significant increase of absolute peak relative helicity during systole and a considerably greater heterogeneous distribution of mean helicity in the aorta. The method has the potential to serve as a reference distribution for comparisons of helical flow between healthy subjects and patients or between different patient groups.
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