The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders.
The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders.
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患者特异性诱导的多能干细胞的效用用于自闭症谱系障碍的建模。
DOI：
10.1007/s00213-013-3196-4
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发表时间：
2014-03
影响因子：
3.4
通讯作者：
Price, Jack
中科院分区：
文献类型：
--
作者：
Cocks, Graham;Curran, Sarah;Gami, Priya;Uwanogho, Dafe;Jeffries, Aaron R.;Kathuria, Annie;Lucchesi, Walter;Wood, Victoria;Dixon, Rosemary;Ogilvie, Caroline;Steckler, Thomas;Price, Jack
到目前为止，精神疾病的模型通常是动物模型。无论是用于进一步了解疾病的病理生理学，还是作为药物发现工具，动物模型都是在实验环境中模拟精神疾病的首选。虽然有细胞模型，但它们通常缺乏有效性。随着患者特异性诱导多能干细胞（iPSC）的出现，这种情况正在发生变化。在这篇文章中，我们给出了一个方法论评估的iPS技术的现状，参考我们自己的工作，在产生患者特异性的iPSCs的自闭症谱系障碍（ASD）的研究。此外，我们将对这项技术的有效性以及在未来几年内它在多大程度上可以补充ASD动物模型提供更广泛的视角。
Until now, models of psychiatric diseases have typically been animal models. Whether they were to be used to further understand the pathophysiology of the disorder, or as drug discovery tools, animal models have been the choice of preference in mimicking psychiatric disorders in an experimental setting. While there have been cellular models, they have generally been lacking in validity. This situation is changing with the advent of patient-specific induced pluripotent stem cells (iPSCs). In this article, we give a methodological evaluation of the current state of the iPS technology with reference to our own work in generating patient-specific iPSCs for the study of autistic spectrum disorder (ASD). In addition, we will give a broader perspective on the validity of this technology and to what extent it can be expected to complement animal models of ASD in the coming years.
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影响因子：
30.8
作者：
Durand, Christelle M.;Betancur, Catalina;Bourgeron, Thomas
通讯作者：
Bourgeron, Thomas
影响因子：
14.5
作者：
Bailey, A;Luthert, P;Lantos, P
通讯作者：
Lantos, P
影响因子：
11
作者：
Durand CM;Perroy J;Loll F;Perrais D;Fagni L;Bourgeron T;Montcouquiol M;Sans N
通讯作者：
Sans N
影响因子：
9.9
作者：
Casanova, MF;Buxhoeveden, DP;Roy, E
通讯作者：
Roy, E
影响因子：
5.7
作者：
Carper, RA;Moses, P;Courchesne, E
通讯作者：
Courchesne, E