Early postnatal decabromodiphenyl ether exposure reduces thyroid hormone and astrocyte density in the juvenile mouse dentate gyrus.
Early postnatal decabromodiphenyl ether exposure reduces thyroid hormone and astrocyte density in the juvenile mouse dentate gyrus.
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DOI：
10.1016/j.physbeh.2020.112798
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发表时间：
2020-03-15
影响因子：
2.9
通讯作者：
Markowski VP
中科院分区：
文献类型：
--
作者：
Edwards CM;Small D;Bell T;David-Drori J;Hansen C;Morris-Schaffer K;Canale C;Ng J;Markowski VP
十溴二苯醚(十溴二苯醚)是一种阻燃剂，几十年来广泛应用于许多消费品。因此，十溴二苯醚及其类别的其他成员已成为全球分布的环境污染物。流行病学和动物研究表明，在大脑发育的关键时期暴露于十溴二苯醚会导致长期的行为损害。目前的研究旨在确定我们实验室在以前的研究中观察到的学习和反应抑制缺陷的潜在神经内分泌机制。C57BL6/J小鼠从出生后第1天至第21天每日单次灌胃0或20 mg/kg十溴二苯醚。在第22天测定血清甲状腺激素水平和海马区三个区域的星形胶质细胞特异性染色。十溴二苯醚暴露显著降低了雄性和雌性小鼠的血清三碘甲状腺原氨酸、甲状腺激素和颗粒下层的星形胶质细胞密度，但不包括肺门或颗粒层。甲状腺激素和/或胶质细胞活性的降低可能损害海马区的发育，导致行为障碍。
Decabromodiphenyl ether (decaBDE) is a flame retardant that was widely-applied to many consumer products for decades. Consequently, decaBDE and other members of its class have become globally-distributed environmental contaminants. Epidemiological and animal studies indicate that decaBDE exposure during critical periods of brain development produces long-term behavioral impairments. The current study was designed to identify potential neuroendocrine mechanisms for learning and response inhibition deficits observed by our lab in a previous study. C57BL6/J mouse pups were given a single daily oral dose of 0 or 20 mg/kg decaBDE from day 1 to 21. Serum thyroid hormone levels and astrocyte-specific staining in three regions of the hippocampus were measured on day 22. DecaBDE exposure significantly reduced serum triiodothyronine, thyroxine, and astrocyte density in the subgranular zone but not the hilus or granular layer in both male and female mice. The reduction of thyroid hormone and/or glia activity could impair hippocampal development, leading to behavior dysfunction.
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DOI：
10.1080/10937404.2011.578556
发表时间：
2011
期刊：
Journal of toxicology and environmental health. Part B, Critical reviews
影响因子：
--
作者：
Parent AS;Naveau E;Gerard A;Bourguignon JP;Westbrook GL
通讯作者：
Westbrook GL
影响因子：
10.4
作者：
Gascon, Mireia;Fort, Marta;Vrijheid, Martine
通讯作者：
Vrijheid, Martine
影响因子：
3.3
作者：
Fujimoto, Hitoshi;Woo, Gye-Hyeong;Shibutani, Makoto
通讯作者：
Shibutani, Makoto
影响因子：
4.6
作者：
Harry, G. Jean;Hooth, Michelle J.;Mouton, Peter R.
通讯作者：
Mouton, Peter R.
DOI：
10.1002/cne.23851
发表时间：
2016-02-15
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Hevner RF
通讯作者：
Hevner RF