Cardiac rehabilitation increases exercise capacity with a reduction of oxidative stress.
Cardiac rehabilitation increases exercise capacity with a reduction of oxidative stress.
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DOI：
10.4070/kcj.2013.43.7.481
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发表时间：
2013-07
影响因子：
2.9
通讯作者：
Nakajima T
中科院分区：
文献类型：
--
作者：
Fukuda T;Kurano M;Fukumura K;Yasuda T;Iida H;Morita T;Yamamoto Y;Takano N;Komuro I;Nakajima T
活性氧（ROS）介导多种信号通路，这些通路是动脉粥样硬化和心血管疾病中血管炎症的基础。心脏康复（CR）具有多种有益作用，包括抗炎作用。本研究的目的是探讨CR对心血管疾病患者ROS的影响。在100例心血管疾病患者CR前和CR后3个月和6个月测量了血清活性氧化代谢产物衍生物（氧化应激指标）水平。生物抗氧化潜力（BAP）测试应用于评估血清的抗氧化能力。CR后3-6个月，静息反应性氧化代谢物水平降低（前：351±97卡拉泰利单位（卡尔U），3个月：329±77卡尔U，6个月：325±63卡尔U，随着V_（O2）峰值预测值百分比和V_（O2）无氧阈预测值百分比（V_（O2）AT）的增加，P均<0.01} B型利钠肽（BNP）降低。CR后6个月BAP试验和抗氧化/氧化应激比值增加。抗氧化/氧化应激比值的变化百分比与V ~ O_2 AT的变化百分比呈正相关，与BNP的变化百分比呈负相关。这些结果表明，强化监督CR显着提高运动能力，这可能是由于适应性反应，涉及更有效的氧化代谢产物或增加的能力，内源性抗氧化系统的心血管疾病患者。
Reactive oxygen species (ROS) mediate various signaling pathways that underlie vascular inflammation in atherogenesis and cardiovascular diseases. Cardiac rehabilitation (CR) has a variety of multiple beneficial effects, including anti-inflammatory effects. The purpose of the present study was to investigate the effects of CR on ROS in patients with cardiovascular diseases. The serum level of derivatives of reactive oxidative metabolites, an index of oxidative stress, was measured in 100 patients with cardiovascular diseases before, and, subsequently, 3 and 6 months after, CR. A biological antioxidant potential (BAP) test was applied to assess the antioxidant power of the serum. The resting reactive oxidative metabolite levels decreased 3-6 months after CR {pre: 351±97 Carratelli unit (CARR U), 3 months: 329±77 CARR U, 6 months: 325±63 CARR U, all p<0.01} with the increase of the percentage of the predicted values of V̇O2 peak and the percentage of the predicted values of V̇O2 at the anaerobic threshold (V̇O2 AT) and the decrease of the B-type natriuretic peptide (BNP). The BAP test and antioxidative/oxidative stress ratio increased 6 months after CR. The % changes of the antioxidative/oxidative stress ratio was positively correlated with the % changes of V̇O2 AT, and negatively correlated with the % changes of the BNP. These results suggest that intensive supervised CR significantly improved exercise capacity, which may be attributable to an adaptive response involving more efficient oxidative metabolites or the increased capacity of endogenous anti-oxidative systems in patients with cardiovascular diseases.
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影响因子：
37.8
作者：
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