Association between body fat distribution and kidney stones: Evidence from a US population.

Association between body fat distribution and kidney stones: Evidence from a US population.
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DOI:
10.3389/fendo.2022.1032323
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发表时间:
2022
影响因子:
5.2
通讯作者:
Hao, Zongyao
Hao, Zongyao
中科院分区:
医学2区
文献类型:
--
作者:
Li, Guoxiang;Liang, Hu;Hao, Yunwu;Huang, Qingfeng;Shen, Xudong;Chen, Yang;Chen, Mingwei;Xi, Junhua;Hao, Zongyao

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我们的目的是评估美国成年人中 Android 与 Gynoid 的比例与肾结石发病率之间的关系。从 2011-2018 年国家健康与营养检查调查 (NHANES) 数据库中选择年龄在 20-59 岁的参与者,利用逻辑回归分析、亚组分析和剂量反应曲线计算来评估 Android 与 Gynoid 比率与肾结石患病率之间的关联。这项研究最终纳入了 10858 名参与者,其中 859 人自我报告有肾结石病史。调整所有混杂因素后,Android 与 Gynoid 比率增加与肾结石患病率增加相关(OR=2.75,95% CI:1.62-4.88)。亚组分析显示,女性(OR=3.55,95% CI:1.54-8.22)、非糖尿病患者(OR=2.59,95% CI:1.45-4.60)、60岁以上年龄≥40岁(OR=3.51,95% CI:1.83-6.71)、墨西哥裔美国人的肾结石患病率增加(OR=4.35,95% CI: 1.40-13.53)和白人(OR=3.86,95% CI:1.82-8.18)组中,A/G比值与肾结石呈显着正相关。相反,在高血压亚组中,A/G 比值与所有组中的肾结石相关。较高的 Android 与 Gynoid 比例与肾结石疾病的高患病率相关。
We aimed to evaluate the relationship between the proportion of Android to Gynoid ratio and the incidence of kidney stones among US adults. Participants aged 20-59 years from the 2011-2018 National Health and Nutrition Examination Survey (NHANES) database were selected to assess the association between Android to Gynoid ratio and kidney stone prevalence using logistic regression analysis, subgroup analysis and calculation of dose-response curves. This study ultimately included 10858 participants, of whom 859 self-reported a history of kidney stones. And after adjusting for all confounders, an increased Android to Gynoid ratio was associated with an increased prevalence of kidney stones (OR=2.75, 95% CI:1.62-4.88). And subgroup analysis showed an increased prevalence of kidney stones in women (OR=3.55, 95% CI: 1.54-8.22), non-diabetic (OR=2.59, 95% CI: 1.45-4.60), 60 > age ≥ 40 years (OR=3.51, 95% CI: 1.83-6.71), Mexican-American (OR=4.35, 95% CI: 1.40- 13.53) and white (OR=3.86, 95% CI: 1.82-8.18) groups, there was a significant positive association between A/G ratio and kidney stones. In contrast, in the hypertensive subgroup, the A/G ratio was associated with kidney stones in all groups. Higher Android to Gynoid ratio is associated with a high prevalence of kidney stone disease.
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