Helicobacter pylori Outer Membrane Vesicles and Extracellular Vesicles from Helicobacter pylori-Infected Cells in Gastric Disease Development.
Helicobacter pylori Outer Membrane Vesicles and Extracellular Vesicles from Helicobacter pylori-Infected Cells in Gastric Disease Development.
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DOI：
10.3390/ijms22094823
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发表时间：
2021-05-01
影响因子：
5.6
通讯作者：
Quest AFG
中科院分区：
文献类型：
--
作者：
González MF;Díaz P;Sandoval-Bórquez A;Herrera D;Quest AFG
细胞外囊泡（extracellular vesicles，EV）是一类细胞源性囊泡，在细胞间通讯中起重要作用，在宿主-病原体相互作用中发挥重要作用，在感染过程中传播病原体源性和宿主源性分子。病原体可以诱导来自感染细胞的EV组成的变化，并使用它们来操纵它们的微环境，例如，以刺激或抑制的方式调节先天性和适应性炎症免疫应答。胃癌是世界范围内癌症相关死亡的主要原因之一，幽门螺杆菌（H。幽门螺杆菌）被认为是发展这种疾病的主要危险因素，其特征在于强烈的炎症成分。感染H.幽门螺旋杆菌对炎症有很大的贡献，并且这样做会促进疾病的发展。此外，H.幽门螺杆菌释放囊泡，称为外膜囊泡（H. pylori-OMV），其有助于胃上皮中的萎缩和细胞转化。本文就H. pylori和H. pylori-OMV与胃癌的发展将被讨论。通过破译这些外部囊泡在H.幽门螺杆菌感染有益于宿主或病原体，新的治疗策略可能会成为预防疾病。
Extracellular vesicles (EVs) are cell-derived vesicles important in intercellular communication that play an essential role in host-pathogen interactions, spreading pathogen-derived as well as host-derived molecules during infection. Pathogens can induce changes in the composition of EVs derived from the infected cells and use them to manipulate their microenvironment and, for instance, modulate innate and adaptive inflammatory immune responses, both in a stimulatory or suppressive manner. Gastric cancer is one of the leading causes of cancer-related deaths worldwide and infection with Helicobacter pylori (H. pylori) is considered the main risk factor for developing this disease, which is characterized by a strong inflammatory component. EVs released by host cells infected with H. pylori contribute significantly to inflammation, and in doing so promote the development of disease. Additionally, H. pylori liberates vesicles, called outer membrane vesicles (H. pylori-OMVs), which contribute to atrophia and cell transformation in the gastric epithelium. In this review, the participation of both EVs from cells infected with H. pylori and H. pylori-OMVs associated with the development of gastric cancer will be discussed. By deciphering which functions of these external vesicles during H. pylori infection benefit the host or the pathogen, novel treatment strategies may become available to prevent disease.
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DOI：
10.1038/nrmicro3480
发表时间：
2015-10
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Brown L;Wolf JM;Prados-Rosales R;Casadevall A
通讯作者：
Casadevall A
影响因子：
5.6
作者：
Ansari S;Gantuya B;Tuan VP;Yamaoka Y
通讯作者：
Yamaoka Y
影响因子：
2.1
作者：
Ayala, Guadalupe;Torres, Luz;Melendez-Zajgla, Jorge
通讯作者：
Melendez-Zajgla, Jorge
影响因子：
4.4
作者：
Butt, Julia;Blot, William J.;Epplein, Meira
通讯作者：
Epplein, Meira
影响因子：
5.8
作者：
Balaji, Kithiganahalli N.;Goyal, Girija;Mohammad, Saleemulla
通讯作者：
Mohammad, Saleemulla