Triphenyl phosphate-induced pericardial edema is associated with elevated epidermal ionocytes within zebrafish embryos.
Triphenyl phosphate-induced pericardial edema is associated with elevated epidermal ionocytes within zebrafish embryos.
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DOI：
10.1016/j.etap.2021.103776
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发表时间：
2022-01
影响因子：
4.3
通讯作者：
Volz DC
中科院分区：
文献类型：
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作者：
Wiegand J;Cheng V;Reddam A;Avila-Barnard S;Volz DC
磷酸三苯酯（TPHP）是一种有机磷酸酯基增塑剂和阻燃剂。本研究的目的是确定表皮离子细胞在介导tphp诱导的斑马鱼胚胎心包水肿中的潜在作用。与时间匹配的胚胎相比，在受精后24至72小时暴露于TPHP导致心包水肿和72小时时离子细胞数量显著增加。此外，胚胎暴露于甘露醇（一种渗透性利尿剂）可阻断tpp诱导的心包水肿和对离子细胞丰度的影响。然而，敲低ATPase1a1.4（一种定位于表皮离子细胞的丰富的Na+/K+- atp酶）可以减轻tpp诱导的离子细胞丰度，但不能减轻心包水肿，而胚胎共同暴露于瓦巴因（一种Na+/K+- atp酶抑制剂）可以增强tpp诱导的心包水肿，但不能增强离子细胞丰度。总的来说，我们的研究结果表明，TPHP可能具有多种毒性机制，导致发育中的斑马鱼胚胎中离子细胞丰度增加和心包水肿。
Triphenyl phosphate (TPHP) is an organophosphate ester-based plasticizer and flame retardant. The objective of this study was to identify the potential role of epidermal ionocytes in mediating TPHP-induced pericardial edema within zebrafish embryos. Exposure to TPHP from 24 to 72 h post fertilization (hpf) resulted in a significant increase in pericardial edema and the number of ionocytes at 72 hpf relative to time-matched embryos treated with vehicle. In addition, co-exposure of embryos to mannitol (an osmotic diuretic) blocked TPHP-induced pericardial edema and effects on ionocyte abundance. However, knockdown of ATPase1a1.4 – an abundant Na+/K+-ATPase localized to epidermal ionocytes – mitigated TPHP-induced effects on ionocyte abundance but not pericardial edema, whereas co-exposure of embryos to ouabain – a Na+/K+-ATPase inhibitor – enhanced TPHP-induced pericardial edema but not ionocyte abundance. Overall, our findings suggest that TPHP may have multiple mechanisms of toxicity leading to an increase in ionocyte abundance and pericardial edema within developing zebrafish embryos.
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影响因子：
2.9
作者：
Jarema KA;Hunter DL;Shaffer RM;Behl M;Padilla S
通讯作者：
Padilla S
影响因子：
2.7
作者：
Jaenicke, Martina;Carney, Thomas J.;Hammerschmidt, Matthias
通讯作者：
Hammerschmidt, Matthias
影响因子：
3.8
作者：
Antkiewicz, DS;Burns, CG;Heideman, W
通讯作者：
Heideman, W
FOXI3A和FOXI3B之间的积极调节环对于斑马鱼表皮离子细胞的规范和分化至关重要。
影响因子：
3.7
作者：
Hsiao, Chung-Der;You, May-Su;Guh, Ying-Jey;Ma, Ming;Jiang, Yun-Jin;Hwang, Pung-Pung
通讯作者：
Hwang, Pung-Pung
DOI：
10.1016/j.aquatox.2015.02.009
发表时间：
2015-04
期刊：
Aquatic toxicology (Amsterdam, Netherlands)
影响因子：
--
作者：
Isales GM;Hipszer RA;Raftery TD;Chen A;Stapleton HM;Volz DC
通讯作者：
Volz DC