Curcumin and Glu-GNPs Induce Radiosensitivity against Breast Cancer Stem-Like Cells.
Curcumin and Glu-GNPs Induce Radiosensitivity against Breast Cancer Stem-Like Cells.
复制标题
姜黄素和 Glu-GNP 诱导乳腺癌干细胞样放射敏感性
DOI：
10.1155/2020/3189217
复制
发表时间：
2020
影响因子：
--
通讯作者：
Hu C
中科院分区：
文献类型：
--
作者：
Yang K;Liao Z;Wu Y;Li M;Guo T;Lin J;Li Y;Hu C
乳腺癌干细胞是乳腺癌患者临床治疗中放疗抵抗的重要原因。如何靶向乳腺癌干细胞是提高乳腺癌放疗疗效的关键。我们首次提出将姜黄素联合葡萄糖纳米金颗粒(Glu-GNPs)用于靶向乳腺癌干细胞以降低放疗抵抗，可显著提高MCF-7和MDA-MB-231乳腺癌干细胞(BCSCs)放疗后的凋亡水平，并具有抗增殖和集落形成的作用。在模拟低氧条件下，姜黄素联合谷氨酸-GNPs可显著提高MCF7和MADMB-231ROS水平，降低HIF-1α和HSP90的表达，从而抑制肿瘤细胞自身的应激能力，促进肿瘤干细胞的凋亡，增强放射治疗的敏感性。本研究结果表明，姜黄素与Glu-GNPs联合应用在缓解肿瘤缺氧和提高BCSCs放射敏感性方面具有很大潜力，为开发高效低毒的新型放射增敏剂提供了科学研究数据。
Breast cancer stem cells are an important cause of radiotherapy resistance in the clinical treatment of breast cancer patients. How to target breast cancer stem cells is the key to improving the efficacy of breast cancer radiotherapy. We proposed for the first time that curcumin combined with glucose nanogold particles (Glu-GNPs) targeted breast cancer stem cells to reduce radiotherapy resistance, which can significantly enhance the apoptosis level of MCF-7 and MDA-MB-231 breast cancer stem-like cells (BCSCs) after radiotherapy and antiproliferation and colony-forming. Under simulated hypoxic conditions, curcumin combined with Glu-GNPs can significantly improve the ROS level of MCF-7 and MDA-MB-231 mammospheres; reduce the expression of HIF-1α and HSP90, thereby inhibiting the tumor cells' own stress ability; promote the apoptosis of tumor stem cells; and enhance the sensitivity of radiotherapy. The current results indicate that the combination of curcumin and Glu-GNPs has great potential to relieve tumor hypoxia and increase radiosensitivity on BCSCs, providing scientific research data for developing a novel radiosensitizer with high efficiency and low toxicity.
登录
查看更多内容
影响因子：
8
作者：
Hu C;Niestroj M;Yuan D;Chang S;Chen J
通讯作者：
Chen J
影响因子：
13.3
作者：
Kong, Tao;Zeng, Jie;Xing, James Z.
通讯作者：
Xing, James Z.
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
3
作者：
Liao, Feng;Liu, Li;Hu, Jian
通讯作者：
Hu, Jian
影响因子：
4.6
作者：
McQuaid HN;Muir MF;Taggart LE;McMahon SJ;Coulter JA;Hyland WB;Jain S;Butterworth KT;Schettino G;Prise KM;Hirst DG;Botchway SW;Currell FJ
通讯作者：
Currell FJ