Ultrasonic viscoelasticity imaging of nonpalpable breast tumors: preliminary results.
Ultrasonic viscoelasticity imaging of nonpalpable breast tumors: preliminary results.
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DOI：
10.1016/j.acra.2008.05.023
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发表时间：
2008-12
影响因子：
4.8
通讯作者：
Insana, Michael F.
中科院分区：
文献类型：
--
作者：
Qiu, Yupeng;Sridhar, Mallika;Tsou, Jean K.;Lindfors, Karen K.;Insana, Michael F.
早期乳腺癌诊断的提高取决于医生是否有能力获得必要的信息来区分难以察觉的恶性肿瘤和良性肿瘤。描述组织力学特性的粘弹性特征可能有助于区分这些类型的病变。本文研究了21例乳腺x线摄影检测到4或5个乳腺病变（良性10例，恶性11例），但病理证实的BI-RADS患者。从超声应变图像的时间序列中提取粘弹性参数，比较良恶性肿瘤的粘弹性参数差异。参数数据用颜色编码并叠加在超声图上。应变延迟时间参数T1对良恶性肿瘤的鉴别效果最好（p<0.01）。T1测量组织在压缩后完全变形（应变）所需的时间，因此它描述了组织对小变形力的时变粘性响应。与周围背景组织相比，恶性病变的平均T1值较小，良性病变的T1值较大。这种组织特异性对比与乳腺间质细胞外基质的已知变化相关。通过添加粘弹性应变成像参数，可改善不可触及乳腺病变的特征。使用延迟时间T1， BI-RADS 4或5肿瘤的良恶性分化尤为明显。
Improvements in the diagnosis of early breast cancers depend on a physician’s ability to obtain the information necessary to distinguish nonpalpable malignant and benign tumors. Viscoelastic features that describe mechanical properties of tissues may help to distinguish these types of lesions. 21 patients with nonpalpable, pathology-confirmed BI-RADS 4 or 5 breast lesions (10 benign, 11 malignant) detected by mammography were studied. Viscoelastic parameters were extracted from a time sequence of ultrasonic strain images and differences in the parameters between malignant and benign tumors were compared. Parametric data were color coded and superimposed on sonograms. The strain retardance time parameter, T1, provided the best discrimination between malignant and benign tumors (p<0.01). T1 measures the time required for tissues to fully deform (strain) once compressed, and therefore it describes the time-varying viscous response of tissue to a small deforming force. Compared to the surrounding background tissues, malignant lesions have smaller average T1 values while benign lesions have larger T1 values. This tissue-specific contrast correlates with known changes in the extracellular matrix of breast stroma. Characterization of nonpalpable breast lesions is improved by the addition of viscoelastic strain imaging parameters. The differentiation of malignant and benign BI-RADS 4 or 5 tumors is especially evident with the use of the retardation time estimates, T1.
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