Mechanisms and Therapeutic Relevance of Neuro-immune Communication.
Mechanisms and Therapeutic Relevance of Neuro-immune Communication.
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DOI：
10.1016/j.immuni.2017.06.008
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发表时间：
2017-06-20
期刊：
影响因子：
32.4
通讯作者：
Tracey KJ
中科院分区：
文献类型：
--
作者：
Chavan SS;Pavlov VA;Tracey KJ
免疫学和神经科学前沿的积极研究已经确定了免疫系统和神经系统之间的多个相互作用和通信点。免疫细胞激活刺激调节先天免疫和适应性免疫的神经元回路。对炎症反射和其他神经免疫相互作用的分子机制见解极大地促进了对免疫的理解，并确定了炎症和自身免疫性疾病的新治疗可能性。最近成功的临床试验，使用生物电子设备，调节炎症反射，显着改善类风湿性关节炎和炎症性肠病提供了一个路径，使用电子作为一种治疗方式，以靶向免疫的分子机制。在这里，我们回顾外周感觉神经元功能调制的免疫挑战和免疫和炎症的神经调节的机制，并讨论这种机制的见解的治疗意义。在这篇综述中，Chavan，Pavlov和Tracey讨论了免疫系统和神经系统界面的机制以及神经通路在免疫调节中的作用。他们还总结了神经调节在炎症和自身免疫性疾病的动物模型和临床环境中的治疗意义。
Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the inflammatory reflex and other neuro-immune interactions have greatly advanced understanding immunity, and identified new therapeutic possibilities in inflammatory and autoimmune diseases. Recent successful clinical trials using bioelectronic devices that modulate the inflammatory reflex to significantly ameliorate rheumatoid arthritis and inflammatory bowel disease provide a path for using electrons as a therapeutic modality to target molecular mechanisms of immunity. Here we review mechanisms of peripheral sensory neuronal function modulation in response to immune challenges and neural regulation of immunity and inflammation, and discuss the therapeutic implications of this mechanistic insight. In this review Chavan, Pavlov and Tracey discuss mechanisms at the interface of the immune system and the nervous system as well as the role of neural pathways in the regulation of immunity. They also summarize the therapeutic implications of neuromodulation in animal models and clinical settings of inflammatory and autoimmune disease.
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影响因子：
16.6
作者：
Carnevale, Daniela;Perrotta, Marialuisa;Pallante, Fabio;Fardella, Valentina;Iacobucci, Roberta;Fardella, Stefania;Carnevale, Lorenzo;Carnevale, Raimondo;De Lucia, Massimiliano;Cifelli, Giuseppe;Lembo, Giuseppe
通讯作者：
Lembo, Giuseppe
DOI：
10.1523/jneurosci.3795-08.2008
发表时间：
2008-12-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Binshtok AM;Wang H;Zimmermann K;Amaya F;Vardeh D;Shi L;Brenner GJ;Ji RR;Bean BP;Woolf CJ;Samad TA
通讯作者：
Samad TA
影响因子：
3.5
作者：
Bonaz, B.;Sinniger, V.;Pellissier, S.
通讯作者：
Pellissier, S.
DOI：
10.4049/jimmunol.1601613
发表时间：
2017-05-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chavan SS;Tracey KJ
通讯作者：
Tracey KJ
DOI：
10.1002/ar.a.20088
发表时间：
2004-09-01
期刊：
ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY
影响因子：
--
作者：
Berthoud, HR
通讯作者：
Berthoud, HR