Dynamic Reorganization of Neuronal Activity Patterns in Parietal Cortex.
Dynamic Reorganization of Neuronal Activity Patterns in Parietal Cortex.
复制标题
DOI：
10.1016/j.cell.2017.07.021
复制
发表时间：
2017-08-24
期刊：
影响因子：
64.5
通讯作者：
Harvey CD
中科院分区：
文献类型：
--
作者：
Driscoll LN;Pettit NL;Minderer M;Chettih SN;Harvey CD
神经元的表征随着感觉刺激和行为动作之间的关联的学习而改变。然而，它是知之甚少，是否表示学习协会稳定在皮层协会区或继续改变学习。我们跟踪了一个月后顶叶皮层神经元的活动，因为小鼠稳定地执行虚拟导航任务。细胞活动和任务特征之间的关系在一天内基本稳定，但在数周内经历了重大重组。提供任务特征（试验类型和迷宫位置）信息的神经元在几天内发生变化。尽管单个细胞发生了变化，但群体活动每天都具有统计学上相似的特性，并且在一周以上的时间内保持稳定的信息。当小鼠学习到更多的关联时，用于现有表征的神经元中出现了新的活动模式，而不会对这些表征的变化率产生很大影响。我们认为，动态神经元活动模式可以平衡学习的可塑性和记忆的稳定性。与感觉刺激的表征或伴随运动动作的活动模式是稳定的想法相反，顶叶皮层中的神经元表征可以在几天内发生变化，这可能允许在稳定的信息编码和整合新信息的灵活性之间进行权衡。
Neuronal representations change as associations are learned between sensory stimuli and behavioral actions. However, it is poorly understood whether representations for learned associations stabilize in cortical association areas or continue to change following learning. We tracked the activity of posterior parietal cortex neurons for a month as mice stably performed a virtual-navigation task. The relationship between cells’ activity and task features was mostly stable on single days but underwent major reorganization over weeks. The neurons informative about task features (trial type and maze locations) changed across days. Despite changes in individual cells, the population activity had statistically similar properties each day and stable information for over a week. As mice learned additional associations, new activity patterns emerged in the neurons used for existing representations without greatly affecting the rate of change of these representations. We propose that dynamic neuronal activity patterns could balance plasticity for learning and stability for memory. Contrary to the idea that representations of sensory stimuli or the activity patterns that accompany motor actions are stable, neuronal representations in the parietal cortex can change across days, possibly allowing for the tradeoff between stable encoding of information and flexibility for incorporating new information.
登录
查看更多内容
影响因子：
16.2
作者：
Aronov, Dmitriy;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
5.3
作者：
Andermann ML;Kerlin AM;Reid RC
通讯作者：
Reid RC
影响因子：
25
作者：
Park, Il Memming;Meister, Miriam L. R.;Huk, Alexander C.;Pillow, Jonathan W.
通讯作者：
Pillow, Jonathan W.
影响因子：
3.7
作者：
MCNAUGHTON, BL;MIZUMORI, SJY;GREEN, EJ
通讯作者：
GREEN, EJ
影响因子：
16.2
作者：
Cromer, Jason A.;Roy, Jefferson E.;Miller, Earl K.
通讯作者：
Miller, Earl K.