Representation of multiple, independent categories in the primate prefrontal cortex.

Representation of multiple, independent categories in the primate prefrontal cortex.
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DOI:
10.1016/j.neuron.2010.05.005
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发表时间:
2010-06-10
期刊:
影响因子:
16.2
通讯作者:
Miller, Earl K.
Miller, Earl K.
中科院分区:
医学1区
文献类型:
--
作者:
Cromer, Jason A.;Roy, Jefferson E.;Miller, Earl K.

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视觉类别的神经相关性先前已经在前额叶皮层(PFC)中被确定。然而,单个神经元是否可以代表多个类别是未知的。PFC中神经元的泛化与特化程度不同已经被理论化。我们记录了猴子在两种不同的独立分类(猫与狗,运动汽车与轿车)之间切换时的侧PFC神经活动。我们发现,许多PFC神经元反映了两种类别的区别。事实上,这些多任务神经元具有最强的类别效应。这与我们实验室最近的一份报告形成了鲜明对比,该报告称,猴子在竞争性分类区分(应用于同一刺激集)之间切换时表现出独立的表征。我们认为,认知需求决定是否PFC神经元的功能类别“多任务”。
Neural correlates of visual categories have been previously identified in the prefrontal cortex (PFC). However, whether individual neurons can represent multiple categories is unknown. Varying degrees of generalization vs. specialization of neurons in the PFC have been theorized. We recorded from lateral PFC neural activity while monkeys switched between two different and independent categorical distinctions (Cats vs. Dogs, Sports Cars vs. Sedans). We found that many PFC neurons reflected both categorical distinctions. In fact, these multitasking neurons had the strongest category effects. This stands in contrast to our lab’s recent report that monkeys switching between competing categorical distinctions (applied to the same stimulus set) showed independent representations. We suggest that cognitive demands determine whether PFC neurons function as category “multi-taskers”.
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发表时间: 2007-03-15
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