Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease.
Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease.
复制标题
转录因子 Blimp-1 在健康和疾病中对单核吞噬细胞的调节。
作者：
Ulmert I;Henriques-Oliveira L;Pereira CF;Lahl K
B 淋巴细胞诱导成熟蛋白-1 (Blimp-1) 是 Prdm1 基因编码的转录因子，在适应性免疫系统中发挥着许多关键作用，可维持 B 细胞和 T 细胞的关键效应功能。新出现的临床数据以及来自小鼠研究的机制证据还确定了 Blimp-1 在单核吞噬细胞 (MNP) 系统维持免疫稳态中的关键功能。 Blimp-1对基因表达的调节影响MNP生物学的各个方面，包括发育程序，例如单核细胞进入外周组织的命运决定，以及功能程序，例如激活、抗原呈递和可溶性炎症介质的分泌。 MNP 中 Blimp-1 表达的高度组织、子集和状态特异性调节表明，Blimp-1 是免疫激活的动态调节因子，可整合环境线索来微调先天细胞的功能。在这篇综述中，我们将讨论有关巨噬细胞和树突状细胞中 Blimp-1 调节和功能的最新知识。 Blimp-1 在单核吞噬细胞 (MNP) 中显示出广泛的表达模式，除了在适应性免疫系统中的已知作用外，它还正在成为先天免疫细胞亚群识别、激活和功能的重要变阻器。我们在此讨论 Blimp-1 在整合环境触发因素和印记 MNP 的特定环境功能以维持免疫稳态方面的新兴前景。
B lymphocyte‐induced maturation protein‐1 (Blimp‐1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B‐ and T‐cells. Emerging clinical data, as well as mechanistic evidence from mouse studies, have additionally identified critical functions of Blimp‐1 in the maintenance of immune homeostasis by the mononuclear phagocyte (MNP) system. Blimp‐1 regulation of gene expression affects various aspects of MNP biology, including developmental programmes such as fate decisions of monocytes entering peripheral tissue, and functional programmes such as activation, antigen presentation and secretion of soluble inflammatory mediators. The highly tissue‐, subset‐ and state‐specific regulation of Blimp‐1 expression in MNPs suggests that Blimp‐1 is a dynamic regulator of immune activation, integrating environmental cues to fine‐tune the function of innate cells. In this review, we will discuss the current knowledge regarding Blimp‐1 regulation and function in macrophages and dendritic cells. Blimp‐1 shows a broad expression pattern in mononuclear phagocytes (MNPs), and is emerging as an important rheostat for innate immune cell subset identity, activation and function, in addition to its known roles in the adaptive immune system. We here discuss the emerging picture of Blimp‐1 in integrating environmental triggers and imprinting context‐specific function of MNPs for the maintenance of immune homeostasis.
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