New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling.
New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling.
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DOI：
10.1016/j.gde.2009.08.004
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发表时间：
2009-10
影响因子：
4
通讯作者：
Yamada, Gen
中科院分区：
文献类型：
--
作者：
Suzuki, Kentaro;Economides, Aris;Yanagita, Motoko;Graf, Daniel;Yamada, Gen
泄殖腔/尿生殖窦及其邻近区域分化为尿生殖/生殖器官。尾退化综合征（CRS;包括美人鱼综合征），一种严重的泄殖腔畸形，表现为后肢融合和泌尿生殖器官缺陷，因此表明这些缺陷是由早期发育过程中的几种形态发生改变引起的。骨形态发生蛋白（Bmp）信号在胚胎后部原条的衰减导致尾部畸形，包括泄殖腔和两后肢的融合。遗传组织谱系研究表明存在协调的器官发生。刺猬（HH）反应细胞来源于泄殖腔周围间充质（PCM）有助于泌尿生殖/生殖器官。这些发现表明存在基于生长因子功能和串扰的泌尿生殖/生殖组织协调器官发生的发育程序。
The cloaca/urogenital sinus and its adjacent region differentiate into the urogenital/reproductive organs. Caudal regression syndrome (CRS; including Mermaid syndrome), a type of severe cloacal malformation displays hindlimb fusion and urogenital organ defects, thus suggesting that such defects are caused by several morphogenetic alterations during early development. The attenuation of Bone Morphogenetic Protein (Bmp) signaling at the posterior primitive streak of embryos leads to the caudal dysmorphogenesis including the cloaca and fusion of both hindlimbs. Genetic tissue lineage studies indicate the presence of coordinated organogenesis. Hedgehog (HH)-responding cells derived from peri-cloacal mesenchyme (PCM) contribute to the urogenital/reproductive organs. These findings indicate the existence o f developmental programs for the coordinated organogenesis of urogenital/reproductive tissues based on growth factor function and crosstalk.
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影响因子：
3.5
作者：
Chassot, Anne-Amandine;Ranc, Fariba;Chaboissier, Marie-Christine
通讯作者：
Chaboissier, Marie-Christine
影响因子：
4.6
作者：
Cobb, J;Duboule, D
通讯作者：
Duboule, D
影响因子：
4
作者：
Barske, Lindsey A.;Capel, Blanche
通讯作者：
Capel, Blanche
影响因子：
4.6
作者：
Brenner-Anantharam, Andrea;Cebrian, Cristina;Herzlinger, Doris
通讯作者：
Herzlinger, Doris
影响因子：
64.8
作者：
GRUNEBERG, H
通讯作者：
GRUNEBERG, H