Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome.
Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome.
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DOI：
10.1016/j.ajog.2003.11.019
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发表时间：
2004-07
影响因子：
9.8
通讯作者：
Tan PY
中科院分区：
文献类型：
--
作者：
Wong SF;Chow KM;Leung TN;Ng WF;Ng TK;Shek CC;Ng PC;Lam PW;Ho LC;To WW;Lai ST;Yan WW;Tan PY
本研究旨在评估严重急性呼吸综合征(SARS)孕妇的妊娠结局和围产儿结局。所有在二00三年二月一日至七月三十一日期间在香港出现严重急性呼吸系统综合症的孕妇(12名)均包括在内。收集妊娠结局和围产儿结局。对脐带血、胎盘组织进行SARS相关冠状病毒逆转录聚合酶链式反应，并对新生儿进行随后的血清学随访，以评估病毒在围产期传播的证据。12名患者中有3人死亡，病死率为25%。在妊娠早期出现的7名患者中，有4名(57%)发生了自发流产。24周后出现的5例患者中有4例早产。两位母亲在没有分娩的情况下康复，但她们正在进行的怀孕因宫内生长受限而复杂化。无一例新生儿出现临床SARS，所有检查均为阴性。怀孕期间的SARS与自然流产、早产和宫内发育受限的高发生率有关。没有证据表明这些母亲所生的婴儿会在围产期感染SARS。
This study was undertaken to evaluate the pregnancy and perinatal outcomes of pregnant women with severe acute respiratory syndrome (SARS). All pregnant women (12) who presented with SARS in Hong Kong between February 1 and July 31, 2003, were included. The pregnancy and perinatal outcomes were collected. Evidence of perinatal transmission of virus was assessed with the SARS-associated coronavirus reverse-transcriptase polymerase chain reaction on cord blood, placenta tissue, and subsequent follow-up of the neonate on serology. Three deaths occurred among the 12 patients, giving a case fatality rate of 25%. Four of the 7 patients (57%) who presented in the first trimester had spontaneous miscarriage. Four of the 5 patients who presented after 24 weeks were delivered preterm. Two mothers recovered without delivery, but their ongoing pregnancies were complicated by intrauterine growth restriction. No newborn infant had clinical SARS and all investigations were negative for SARS. SARS during pregnancy is associated with high incidences of spontaneous miscarriage, preterm delivery, and intrauterine growth restriction. There is no evidence of perinatal SARS infection among infants born to these mothers.
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DOI：
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发表时间：
1993-05-01
影响因子：
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作者：
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期刊：
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