Can serum interleukin-2 receptor alpha predict lymph node metastasis in early gastric cancer?
Can serum interleukin-2 receptor alpha predict lymph node metastasis in early gastric cancer?
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DOI：
10.4174/jkss.2012.82.3.143
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发表时间：
2012-03
影响因子：
--
通讯作者：
Kim S
中科院分区：
文献类型：
--
作者：
Baik YH;An JY;Noh JH;Sohn TS;Kim S
虽然局部切除如内镜粘膜切除术是早期胃癌的一种治疗选择，但这种方法最重要的缺点之一是无法预测淋巴结转移。本研究旨在探讨血清可溶性白细胞介素2受体α（IL-2 R α）水平对早期胃癌淋巴结转移的预测价值。在三星医疗中心对86例接受胃切除术联合D2淋巴结切除术的早期胃癌患者和20例健康对照者进行术前血清IL-2 R α水平评估。术后对患者的年龄、性别、肿瘤大小、浸润深度、组织学分化和内镜检查结果进行了回顾。根据浸润深度将粘膜下病变分为3层（sm 1、sm 2和sm 3）。淋巴结转移16例（18.6%）。经统计学分析，血清IL-2 R α水平是未分化胃癌淋巴结转移的重要预测因子，血清IL-2 R α水平预测淋巴结转移的临界值为200 U/mL。血清IL-2 R α水平可能是早期未分化胃癌淋巴结转移的良好预测指标。
Although local resection like endoscopic mucosal resection for early gastric cancer is accepted as a treatment option, one of the most important drawbacks of such an approach is the inability to predictlymph node metastasis. The aim of this study was to evaluate the serum soluble receptor alpha for interleukin-2 (IL-2Rα) level as a predictor of lymph node metastasis in the patients with early gastric cancer. Assessment of pre-operative serum IL-2Rα levels was performed on 86 patients with early gastric cancer treated by gastrectomies combined with D2 lymph node resections and 20 healthy controls at Samsung Medical Center. Data on patient age and gender, tumor size, depth of invasion, histologic differentiation, and endoscopic findings were reviewed post-operatively. The submucosal lesions were divided into three layers (sm1, sm2, and sm3) in accordance with the depth of invasion. Lymph node metastasis was observed in 16 patients (18.6%). Statistically, the serum IL-2Rα level was an important predictive factor of lymph node metastasis in undifferentiated gastric cancer, and the cut-off point for the predictive value of serum IL-2Rα level was 200 U/mL. The serum IL-2Rα level might be a good predictor of lymph node metastasis in undifferentiated early gastric cancer.
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