Associations of observed preschool performance monitoring with brain functional connectivity in adolescence.
Associations of observed preschool performance monitoring with brain functional connectivity in adolescence.
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DOI：
10.1016/j.cortex.2021.05.015
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Barch DM
中科院分区：
文献类型：
--
作者：
Gilbert KE;Wheelock MD;Kandala S;Eggebrecht AT;Luby JL;Barch DM
监控一个人的表现有助于发现错误并进行调整以防止将来再犯错误。然而，提高绩效监控与检查行为和完美主义的增加有关，并且是多种精神疾病的特征。了解幼儿时期加强的表现监测与随后的大脑连接之间的关系可能会阐明影响大脑和精神结果的机械风险因素。本研究的目的是探讨学龄前儿童的表现监测与青春期功能连接之间的关联。在当前的前瞻性纵向研究中，我们使用背侧前扣带皮层（dACC）种子进行基于种子的功能连接分析，以评估学龄前儿童观察编码表现监测和青少年功能连接之间的大脑行为关系（n = 79）。我们还利用富集分析来研究网络级连接组范围的关联。基于种子的分析显示，学前表现监测与青少年 fc 在 dACC 与眶额和背外侧前额叶皮层之间呈负相关，而在 dACC-枕叶皮层连接之间观察到正相关。富集分析显示，学前表现监测与运动（MOT）-扣带盖（CO）和显着性（SN）-奖励（REW）之间的连接呈负相关，而与 MOT-DMN 和小脑（CB）-运动连接之间呈正相关。幼儿期表现监测的提高与青春期认知控制、感觉运动处理和皮质-纹状体-丘脑-皮质（CTSC）畸变相关的区域和网络的功能连接有关。这些区域和网络与以表现监测升高为特征的精神疾病有关。研究结果揭示了幼儿期的机械性危险因素与神经功能的长期关联。
Monitoring one’s performance helps detect errors and adapt to prevent future mistakes. However, elevated performance monitoring is associated with increased checking behaviors and perfectionism and is characteristic of multiple psychiatric disorders. Understanding how heightened performance monitoring in early childhood relates to subsequent brain connectivity may elucidate mechanistic risk factors that influence brain and psychiatric outcomes. The aim of this study was to examine the association between performance monitoring in preschool-aged children and functional connectivity during adolescence. In the current prospective longitudinal study, we performed seed-based functional connectivity analysis using a dorsal anterior cingulate cortex (dACC) seed to assess brain-behavior relationships between observationally coded performance monitoring in preschool-aged children and adolescent functional connectivity (n=79). We also utilized enrichment analysis to investigate network-level connectome-wide associations. Seed-based analysis revealed negative correlations between preschool performance monitoring and adolescent fc between dACC and orbitofrontal and dorsolateral prefrontal cortex while a positive correlation was observed between dACC-occipital cortex connectivity. Enrichment analysis revealed a negative correlation between preschool performance monitoring and connectivity between motor (MOT) - cingulo-opercular (CO) and salience (SN) - Reward (REW) and a positive correlation with MOT-DMN, and cerebellum (CB) - motor connectivity. Elevated performance monitoring in early childhood is associated with functional connectivity during adolescence in regions and networks associated with cognitive control, sensorimotor processing and cortico-striatal-thalamic-cortico (CTSC) aberrations. These regions and networks are implicated in psychiatric disorders characterized by elevated performance monitoring. Findings shed light on a mechanistic risk factor in early childhood with long-term associations with neural functioning.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.4
作者：
Backes C;Rühle F;Stoll M;Haas J;Frese K;Franke A;Lieb W;Wichmann HE;Weis T;Kloos W;Lenhof HP;Meese E;Katus H;Meder B;Keller A
通讯作者：
Keller A
影响因子：
8.2
作者：
GEHRING, WJ;GOSS, B;DONCHIN, E
通讯作者：
DONCHIN, E
DOI：
10.1097/01.chi.0000205705.71194.b8
发表时间：
2006-05-01
影响因子：
13.3
作者：
Egger, HL;Erkanli, A;Angold, A
通讯作者：
Angold, A
影响因子：
9.3
作者：
Cuthbert BN;Insel TR
通讯作者：
Insel TR