Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons.
Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons.
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背侧海马到伏隔核的投射通过激活伏隔强啡肽神经元来驱动强化。
DOI：
10.1038/s41467-024-44836-9
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发表时间：
2024-01-29
影响因子：
16.6
通讯作者：
Moron, Jose A.
中科院分区：
文献类型：
--
作者：
Ibrahim, Khairunisa Mohamad;Massaly, Nicolas;Yoon, Hye-Jean;Sandoval, Rossana;Widman, Allie J.;Heuermann, Robert J.;Williams, Sidney;Post, William;Pathiranage, Sulan;Lintz, Tania;Zec, Azra;Park, Ashley;Yu, Waylin;Kash, Thomas L.;Gereau, Robert W.;Moron, Jose A.
海马体是整合情绪处理、学习、记忆和奖励相关行为的关键。背侧海马（dHPC）对于情景记忆、空间记忆和联想记忆尤其重要，并且已被证明是情境和线索相关奖励行为所必需的。中脑边缘核（NAc）是中脑边缘奖赏通路的中枢结构，整合了厌恶性和奖赏性刺激的显著性。尽管对dHPC→NAc直接投射进行了广泛的研究，但它们在驱动强化和奖励相关行为方面的充分性仍有待确定。我们的研究证实，激活dHPC中的兴奋性神经元足以通过其直接投射到NAc壳的背内侧亚区（dmNAcSh）来诱导强化行为。值得注意的是，含有强啡肽的神经元特别有助于dHPC驱动的强化行为，即使含有dmNAcSh强啡肽和脑啡肽的神经元都被dHPC刺激激活。我们的发现揭示了一条控制强化的途径，推进了我们对海马回路在奖励寻求行为中作用的理解。背侧海马在驱动强化中的作用仍有待确定。在这里，作者表明，背侧海马驱动的强化行为是通过输入到背内侧核的强啡肽神经元介导的。
The hippocampus is pivotal in integrating emotional processing, learning, memory, and reward-related behaviors. The dorsal hippocampus (dHPC) is particularly crucial for episodic, spatial, and associative memory, and has been shown to be necessary for context- and cue-associated reward behaviors. The nucleus accumbens (NAc), a central structure in the mesolimbic reward pathway, integrates the salience of aversive and rewarding stimuli. Despite extensive research on dHPC→NAc direct projections, their sufficiency in driving reinforcement and reward-related behavior remains to be determined. Our study establishes that activating excitatory neurons in the dHPC is sufficient to induce reinforcing behaviors through its direct projections to the dorso-medial subregion of the NAc shell (dmNAcSh). Notably, dynorphin-containing neurons specifically contribute to dHPC-driven reinforcing behavior, even though both dmNAcSh dynorphin- and enkephalin-containing neurons are activated with dHPC stimulation. Our findings unveil a pathway governing reinforcement, advancing our understanding of the hippocampal circuity’s role in reward-seeking behaviors. The role of dorsal hippocampus in driving reinforcement remains to be determined. Here, authors show that dorsal hippocampus-driven reinforcing behaviors are mediated via inputs to dynorphin neurons in the dorsal medial nucleus accumbens.
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影响因子：
3.3
作者：
Lasseter HC;Xie X;Ramirez DR;Fuchs RA
通讯作者：
Fuchs RA
DOI：
10.1523/jneurosci.5458-12.2013
发表时间：
2013-05-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Komorowski RW;Garcia CG;Wilson A;Hattori S;Howard MW;Eichenbaum H
通讯作者：
Eichenbaum H
影响因子：
5.3
作者：
GODDARD, GV;MCINTYRE, DC;LEECH, CK
通讯作者：
LEECH, CK
影响因子：
2.5
作者：
DEBANNE, D;GUERINEAU, NC;THOMPSON, SM
通讯作者：
THOMPSON, SM
影响因子：
7.6
作者：
Fakira, Amanda K.;Massaly, Nicolas;Moron, Jose A.
通讯作者：
Moron, Jose A.