Differential neural sensitivity to social inclusion and exclusion in adolescents in foster care.
Differential neural sensitivity to social inclusion and exclusion in adolescents in foster care.
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寄养的青少年对社会包容和排斥的差异神经敏感性。
DOI：
10.1016/j.nicl.2022.102986
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Pfeifer JH
中科院分区：
文献类型：
--
作者：
Vijayakumar N;Cheng TW;Flannery JE;Flournoy JC;Ross G;Mobasser A;Op de Macks Z;Fisher PA;Pfeifer JH
寄养青年和控制组在对社会互动的神经敏感度上有所不同。寄养青少年对排斥有更大的外侧前额叶反应。他们对包容的神经反应也更少。其中一些神经模式是由不良的童年经历驱动的。神经模式也与寄养青少年的外化问题有关。寄养的青少年可能表现出不同的大脑功能模式，这有助于他们普遍的社会情感挑战。然而，有牵连的神经过程的调查有限，特别是在社会领域。因此，本研究调查了寄养青少年对排斥和包容同伴互动的神经反应。参与者包括11-18岁的寄养青少年（N = 69）和社区样本（N = 69）。他们完成了对赛博球（一种虚拟投球模式）的fMRI改编，其中包括排斥和过度包容的时期。为了研究神经对同伴社会经验的敏感性，我们量化了神经反应，这些神经反应以连续的包容和排斥相互作用（使用参数调制器）进行缩放。与社区样本相比，寄养青少年对前额外侧连续排斥事件的反应增强，而对顶叶内沟和颞枕皮质连续包容事件的反应减弱。此外，探索性分析显示，背外侧前额叶对排斥的激活与外化问题有关，特别是在寄养样本中。研究结果强调，寄养青少年对排他性的神经敏感性更高，对包容性的同伴互动的神经敏感性更低。前额叶集群的参与可能反映了排斥过程中更大的显著性和情绪调节过程，而顶叶和颞叶集群可能反映了包容过程中注意力和行为参与的减少。因此，寄养参与与同伴互动过程中神经反应的广泛变化有关，进一步说，这些可能与在弱势群体中发现的外化问题有关。
Foster care youth and controls differ in neural sensitivity to social interactions. Foster care youth have greater lateral prefrontal response to exclusion. They also have less neural response to inclusion. Some of these neural patterns are driven by adverse childhood experiences. Neural patterns are also related to externalizing problems in foster care youth. Adolescents in foster care may exhibit differential patterns of brain functioning that contribute to their pervasive socioemotional challenges. However, there has been limited investigation of implicated neural processes, particularly in the social domain. Thus, the current study investigated neural responses to exclusionary and inclusionary peer interactions in adolescents in foster-care. Participants comprised adolescents aged 11–18 years in foster care (N = 69) and a community sample (N = 69). They completed an fMRI adaptation of Cyberball, a virtual ball-throwing paradigm, that included periods of exclusion and over-inclusion. To investigate neural sensitivity to peer social experiences, we quantified neural responses that scaled with consecutive inclusionary and exclusionary interactions (using parametric modulators). Relative to the community sample, adolescents in foster care exhibited increasing response to consecutive exclusionary events in lateral prefrontal regions and decreasing response to consecutive inclusionary events in the intraparietal sulcus and temporo-occipital cortex. Further, exploratory analyses revealed that dorsolateral prefrontal activation to exclusion was related to externalizing problems, particularly in the foster care sample. Findings highlight greater neural sensitivity to exclusionary, and lesser sensitivity to inclusionary, peer interactions in adolescents in foster care. Engagement of prefrontal clusters may reflect greater salience and emotion regulatory processes during exclusion, while parietal and temporal clusters may reflect reduced attention and behavioural engagement during inclusion. Thus foster care involvement is associated with broad changes in neural responses during peer interactions, and further these potentially relate to externalizing problems that have been identified in this vulnerable population.
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