NKG2D Ligands in Tumor Immunity: Two Sides of a Coin.
NKG2D Ligands in Tumor Immunity: Two Sides of a Coin.
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肿瘤免疫中的 NKG2D 配体： 硬币的两面
DOI：
10.3389/fimmu.2015.00097
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发表时间：
2015
影响因子：
7.3
通讯作者：
Wu JD
中科院分区：
文献类型：
--
作者：
Zhang J;Basher F;Wu JD
The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is expressed on the surface of all human NK, NKT, CD8+ T, and subsets of γδ+ T cells. The significance of NKG2D function in tumor immunity has been well demonstrated in experimental animal models. However, the role of human NKG2D ligands in regulating tumor immunity and cancer prognosis had been controversial in the literature. In this review, we summarize the latest advancement, discuss the controversies, and present evidence that membrane-bound and soluble NKG2D ligands oppositely regulate tumor immunity. We also discuss new perspectives of targeting NKG2D ligands for cancer immunotherapy.
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影响因子：
29.4
作者：
Allez, Matthieu;Tieng, Vannary;Toubert, Antoine
通讯作者：
Toubert, Antoine
影响因子：
11.2
作者：
Ashiru O;Boutet P;Fernández-Messina L;Agüera-González S;Skepper JN;Valés-Gómez M;Reyburn HT
通讯作者：
Reyburn HT
影响因子：
6.4
作者：
Holdenrieder, S;Stieber, P;Salih, HR
通讯作者：
Salih, HR
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
Spies, T
DOI：
10.1073/pnas.93.22.12445
发表时间：
1996-10-29
影响因子：
11.1
作者：
Groh, V;Bahram, S;Spies, T
通讯作者：
Spies, T