Gut microbiota is not modified by Randomized, Double-blind, Placebo-controlled Trial of VSL#3 in Diarrhea-predominant Irritable Bowel Syndrome.
Gut microbiota is not modified by Randomized, Double-blind, Placebo-controlled Trial of VSL#3 in Diarrhea-predominant Irritable Bowel Syndrome.
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DOI：
10.1007/s12602-010-9059-y
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发表时间：
2011-03
影响因子：
4.9
通讯作者：
Kenche, Harshavardhan
中科院分区：
文献类型：
--
作者：
Michail, Sonia;Kenche, Harshavardhan
肠易激综合征(IBS)是一种常见的疾病，对许多人的生活质量产生负面影响。这种疾病的确切病因在很大程度上尚不清楚；然而，新出现的研究表明，肠道微生物区系是一个促成因素。几项临床试验表明，益生菌，如VSL#3，可以对IBS有良好的效果。这项双盲、随机、安慰剂对照研究在以腹泻为主的IBS受试者中进行，以调查VSL#3对粪便微生物区系的影响。利用高通量芯片技术检测16S RNA，研究粪便微生物区系的细菌组成。24名受试者随机接受VSL#3或安慰剂治疗8周。使用GSR和生活质量问卷监测IBS症状。在VSL#3组中，饱腹感分量表出现了有利的变化。然而，益生菌的消费并没有改变肠道微生物区系。在这项研究中，没有遇到任何不良事件或任何安全问题。综上所述，在这项先导研究中使用VSL#3是安全的，并且在以腹泻为主的IBS受试者中显示出特定的GSRs-IBS评分的改善。肠道微生物区系不受VSL#3摄入的影响，这表明其作用机制与微生物区系没有直接联系。
Irritable Bowel Syndrome (IBS) is a common condition that negatively impacts the quality of life for many individuals. The exact etiology of this disorder is largely unknown; however, emerging studies suggest that the gut microbiota is a contributing factor. Several clinical trials show that probiotics, such as VSL#3, can have a favorable effect on IBS. This double-blind, randomized placebo-controlled study has been conducted in diarrhea-predominant IBS subjects in order to investigate the effect of VSL#3 on the fecal microbiota. The bacterial composition of the fecal microbiota was investigated using high-throughput microarray technology to detect 16S RNA. Twenty four subjects were randomized to receive VSL#3 or placebo for 8 weeks. IBS symptoms were monitored using GSRS and quality of life questionnaires. A favorable change in Satiety subscale was noted in the VSL #3 groups. However, the consumption of the probiotic did not change the gut microbiota. There were no adverse events or any safety concerns encountered during this study. To summarize, the use of VSL#3 in this pilot study was safe and showed improvement in specific GSRS-IBS scores in diarrhea-predominant IBS subjects. The gut microbiota was not affected by VSL#3 consumption suggesting that the mechanism of action is not directly linked to the microbiota.
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影响因子：
168.9
作者：
King, TS;Elia, M;Hunter, JO
通讯作者：
Hunter, JO
影响因子：
3.9
作者：
Nikfar, Shekoufeh;Rahimi, Roja;Abdollahi, Mohammad
通讯作者：
Abdollahi, Mohammad
影响因子：
--
作者：
Hamilton-Miller, J. M. T.
通讯作者：
Hamilton-Miller, J. M. T.
影响因子：
2.4
作者：
Hoveyda N;Heneghan C;Mahtani KR;Perera R;Roberts N;Glasziou P
通讯作者：
Glasziou P
影响因子：
3.1
作者：
Codling, Caroline;O'Mahony, Liam;Marchesi, Julian R.
通讯作者：
Marchesi, Julian R.