Anosognosia in hoarding disorder is predicted by alterations in cognitive and inhibitory control.
Anosognosia in hoarding disorder is predicted by alterations in cognitive and inhibitory control.
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DOI：
10.1038/s41598-022-25532-4
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发表时间：
2022-12-16
影响因子：
4.6
通讯作者：
Rodriguez, Carolyn, I
中科院分区：
文献类型：
--
作者：
van Roessel, Peter J.;Marzke, Cassandra;Varias, Andrea D.;Mukunda, Pavithra;Asgari, Sepehr;Sanchez, Catherine;Shen, Hanyang;Jo, Booil;Gunaydin, Lisa A.;Williams, Leanne M.;Rodriguez, Carolyn, I
自知力障碍对精神疾病的发病率有显著影响。病感失认症的神经学概念，反映了疾病的元认知意识的缺陷，越来越多地被理解为与精神病理学有关，但在精神分裂症以外的精神疾病中很少被探讨。我们探讨了病感失认症作为一个方面的自知力障碍，在n = 71人与DSM-5囤积障碍。我们使用了一个标准化的杂乱程度的措施，以评估是否个人囤积症漏报家庭杂乱水平相对于独立的考官。然后，我们探讨是否漏报，作为病感失认症的代理，是预测临床或神经认知行为措施。我们发现，囤积障碍的个人低估了他们的混乱，而低估是由混乱的客观严重性预测。在一个n = 53的参与者子集中，我们发现，低报是通过认知控制和抑制测试，特别是Go/No-Go和Stroop测试的改变来预测的。低报与客观杂乱的关系，囤积障碍的主要症状，表明病感失认症可能反映了该疾病的核心病理生理学。杂波漏报的神经认知预测表明，疾病感失认症囤积障碍共享的元认知意识缺陷在其他神经精神疾病的神经基础和执行疾病感失认症可能是一个跨诊断的精神病理学表现。
Insight impairment contributes significantly to morbidity in psychiatric disorders. The neurologic concept of anosognosia, reflecting deficits in metacognitive awareness of illness, is increasingly understood as relevant to psychopathology, but has been little explored in psychiatric disorders other than schizophrenia. We explored anosognosia as an aspect of insight impairment in n = 71 individuals with DSM-5 hoarding disorder. We used a standardized clutter severity measure to assess whether individuals with hoarding disorder underreport home clutter levels relative to independent examiners. We then explored whether underreporting, as a proxy for anosognosia, is predicted by clinical or neurocognitive behavioral measures. We found that individuals with hoarding disorder underreport their clutter, and that underreporting is predicted by objective severity of clutter. In an n = 53 subset of participants, we found that underreporting is predicted by altered performance on tests of cognitive control and inhibition, specifically Go/No-Go and Stroop tests. The relation of underreporting to objective clutter, the cardinal symptom of hoarding disorder, suggests that anosognosia may reflect core pathophysiology of the disorder. The neurocognitive predictors of clutter underreporting suggest that anosognosia in hoarding disorder shares a neural basis with metacognitive awareness deficits in other neuropsychiatric disorders and that executive anosognosia may be a transdiagnostic manifestation of psychopathology.
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影响因子：
4
作者：
Ayers, Catherine R.;Wetherell, Julie Loebach;Schiehser, Dawn;Almklov, Erin;Golshan, Shahrokh;Saxena, Sanjaya
通讯作者：
Saxena, Sanjaya
影响因子：
10.5
作者：
DAVID, AS
通讯作者：
DAVID, AS
DOI：
10.1098/rstb.2012.0002
发表时间：
2012-05-19
影响因子：
6.3
作者：
David, Anthony S.;Bedford, Nicholas;Gilleen, James
通讯作者：
Gilleen, James
DOI：
10.1016/j.pnpbp.2011.05.012
发表时间：
2011-08-15
影响因子：
5.6
作者：
Jakubovski, Ewgeni;Pittenger, Christopher;Torres, Albina Rodrigues;Fontenelle, Leonardo Franklin;do Rosario, Maria Conceicao;Ferroo, Ygor Arzeno;de Mathis, Maria Alice;Miguel, Euripedes Constantino;Bloch, Michael H.
通讯作者：
Bloch, Michael H.
右前岛叶和右眼眶额叶皮层之间的静息态功能连接与强迫症的洞察力水平相关
DOI：
10.1016/j.nicl.2017.04.002
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Fan J;Zhong M;Zhu X;Gan J;Liu W;Niu C;Liao H;Zhang H;Yi J;Tan C
通讯作者：
Tan C