Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation.
Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation.
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DOI：
10.3390/cells11010018
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发表时间：
2021-12-22
期刊：
影响因子：
6
通讯作者：
Obukhov AG
中科院分区：
文献类型：
--
作者：
Munjuluri S;Wilkerson DA;Sooch G;Chen X;White FA;Obukhov AG
辣椒素是瞬时受体电位香草素1型（TRPV 1）通道的有效激动剂，并且是在辣椒属植物的果实中发现的常见组分，辣椒属植物已经为人类所知并且在食物中食用了大约7000-9000年。辣椒属植物的果实，如辣椒，长期以来一直被认为具有很高的营养价值。此外，辣椒素本身已被提出表现出血管扩张、抗微生物、抗癌和抗伤害感受特性。然而，越来越多的证据显示辣椒素通过血管TRPV 1通道起作用的血管收缩潜力，并表明不必要的辣椒素高消费可能导致严重的后果，包括潜在炎症条件下的血管痉挛和心肌梗死。本文综述了内源性表达于血管平滑肌和内皮细胞的TRPV 1通道，并强调了炎症在TRPV 1通道对辣椒素激活敏感性中的作用。辣椒素的有益血管舒张作用和其不必要的血管收缩作用之间的平衡倾斜可能会导致不良结果，如血管痉挛和心肌梗死，特别是在促炎介质的存在下。
Capsaicin is a potent agonist of the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel and is a common component found in the fruits of the genus Capsicum plants, which have been known to humanity and consumed in food for approximately 7000–9000 years. The fruits of Capsicum plants, such as chili pepper, have been long recognized for their high nutritional value. Additionally, capsaicin itself has been proposed to exhibit vasodilatory, antimicrobial, anti-cancer, and antinociceptive properties. However, a growing body of evidence reveals a vasoconstrictory potential of capsaicin acting via the vascular TRPV1 channel and suggests that unnecessary high consumption of capsaicin may cause severe consequences, including vasospasm and myocardial infarction in people with underlying inflammatory conditions. This review focuses on vascular TRPV1 channels that are endogenously expressed in both vascular smooth muscle and endothelial cells and emphasizes the role of inflammation in sensitizing the TRPV1 channel to capsaicin activation. Tilting the balance between the beneficial vasodilatory action of capsaicin and its unwanted vasoconstrictive effects may precipitate adverse outcomes such as vasospasm and myocardial infarction, especially in the presence of proinflammatory mediators.
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影响因子：
16.2
作者：
Cao E;Cordero-Morales JF;Liu B;Qin F;Julius D
通讯作者：
Julius D
影响因子：
3.1
作者：
Alothman, Zeid Abdullah;Wabaidur, Saikh Mohammad;Ahmed, Yacine Badjah Hadj
通讯作者：
Ahmed, Yacine Badjah Hadj
影响因子：
9.8
作者：
Avraham, Yosefa;Zolotarev, Olga;Berry, Elliot M.
通讯作者：
Berry, Elliot M.
影响因子：
4.6
作者：
Chen, Xingjuan;Duan, Yaqian;Obukhov, Alexander G.
通讯作者：
Obukhov, Alexander G.
DOI：
10.1080/19336950.2016.1185579
发表时间：
2016-09-02
期刊：
Channels (Austin, Tex.)
影响因子：
--
作者：
Andrei SR;Sinharoy P;Bratz IN;Damron DS
通讯作者：
Damron DS