New pharmaceutical treatment of gastric MALT lymphoma: anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib.
New pharmaceutical treatment of gastric MALT lymphoma: anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib.
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DOI：
10.2174/13816128113199990420
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发表时间：
2014
影响因子：
3.1
通讯作者：
Tsuchimoto K
中科院分区：
文献类型：
--
作者：
Nakamura M;Takahashi T;Matsui H;Takahashi S;Murayama SY;Suzuki H;Tsuchimoto K
除了根除幽门螺杆菌、抗癌药物化疗和放射治疗外，包括CD 20拮抗剂利妥昔单抗在内的分子靶向药物治疗是有希望的新方案之一。粘膜相关淋巴组织（MALT）淋巴瘤的组织学特征是由未成熟的毛细血管、毛细血管和微静脉组成的丰富的微血管网络，这种微血管网络除了直接作用于积聚的B淋巴细胞外，还可能成为新的药物治疗的靶点。本研究采用海氏螺杆菌（H. Heilmannii）经口感染C57 BL/6小鼠。由该模型诱导的疾病与人对应物非常相似，因为人MALT淋巴瘤的淋巴上皮病变特征以及血管内皮生长因子（VEGF）及其受体Flt-1、Flk-1和Flt-4的丰富血管形成和定位。通过给予VEGF受体抗体或塞来昔布（一种环氧合酶2抑制剂），我们能够诱导肿瘤大小的显著减小和微血管网内皮细胞的凋亡变化。这些抗血管生成策略被认为是胃MALT淋巴瘤的新药物治疗的候选者，当其他治疗方法无效时。
In addition to eradication of Helicobacter pylori, chemotherapy with anticancer agents, and radiation therapy, the treatment with molecular target drugs including rituximab, a CD20 antagonist, is one of the promising new regimens. The mucosa-associated lymphoid tissue (MALT) lymphoma is histologically characterized by rich distribution of the microvascular network consisting of the immature capillaries, lymphatics and venules, and this microvascular network could be the target of the new pharmacotherapy in addition to the direct action on the accumulated B lymphocytes. We have established the animal model of the gastric MALT lymphoma by the Helicobacter heilmannii (H. heilmannii) peroral infection of C57BL/6 mice. The disease induced by this model is very similar to the human counterpart, because of the lymphoepithelial lesion characteristic of the human MALT lymphoma as well as the rich vascularization and localization of vascular endothelial growth factor (VEGF) and its receptors, Flt-1, Flk-1 and Flt-4. By administering VEGF receptor antibodies or celecoxib, one of the cyclooxygenase 2 inhibitors, we were able to induce a significant decrease in the size of the tumor and the apoptotic changes of the endothelial cells of the microvascular network. These antiangiogenic strategies were suggested to be candidates for the new pharmacological treatment of gastric MALT lymphoma, when other treatments are not effective.
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影响因子：
3.7
作者：
Saito Y;Suzuki H;Tsugawa H;Imaeda H;Matsuzaki J;Hirata K;Hosoe N;Nakamura M;Mukai M;Saito H;Hibi T
通讯作者：
Hibi T
影响因子：
3.3
作者：
GENTA, RM;HUBERMAN, RM;GRAHAM, DY
通讯作者：
GRAHAM, DY
DOI：
10.1073/pnas.0708865104
发表时间：
2007-11-20
影响因子：
11.1
作者：
Rudge, John S.;Holash, Jocelyn;Yancopoulos, George D.
通讯作者：
Yancopoulos, George D.
DOI：
10.1111/j.1440-1746.2010.06230.x
发表时间：
2010-05-01
影响因子：
4.1
作者：
Nakamura, Masahiko;Matsui, Hidenori;Tsuchimoto, Kanji
通讯作者：
Tsuchimoto, Kanji
影响因子：
--
作者：
Sugito, M;Araki, K;Ogata, T
通讯作者：
Ogata, T