Seasonality and clinical impact of human parainfluenza viruses.
Seasonality and clinical impact of human parainfluenza viruses.
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DOI：
10.1111/irv.12597
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发表时间：
2018-11
影响因子：
4.4
通讯作者：
Saiman L
中科院分区：
文献类型：
--
作者：
Maykowski P;Smithgall M;Zachariah P;Oberhardt M;Vargas C;Reed C;Demmer RT;Stockwell MS;Saiman L
呼吸道病毒快速诊断检测的广泛可用性允许对人类副流感病毒（HPIV）进行更深入的研究。本研究旨在评估HPIV 1 - 4型的季节性、HPIV类型的临床结局以及疾病严重程度的风险因素。这项回顾性研究于2013年1月至2015年12月在儿童和成人HPIV患者中进行，通过多重逆转录聚合酶链反应检测，参与纽约市急性呼吸道感染（阿里斯）的社区监测研究，并在同一社区的三级护理中心住院。季节性趋势的HPIV类型之间进行了比较社区和医院组。评估HPIV类型、人口统计学、临床特征和疾病严重程度之间的相关性。在1753名社区监测参与者（中位年龄9.2岁）和680名住院患者（中位年龄6.8岁）中，有69名（4%）检测到HPIV。HPIV 1 - 3型的季节性与先前描述的模式一致; HPIV-4型每年发生在夏末和秋季。在社区队列中，22名（32%）参与者寻求医疗护理，9名（13%）报告使用抗生素，20名（29%）报告错过工作或学校≥1天。在住院患者中，24%有≥4种慢性疾病。多变量有序logistic回归表明，疾病严重程度增加与儿童中HPIV-4和慢性心血管和呼吸系统疾病显著相关，与成人中年龄≥65岁和慢性呼吸系统疾病显著相关。HPIV-4每年在夏末秋初出现，与住院儿童的疾病严重程度增加相关。
Widespread availability of rapid diagnostic testing for respiratory viruses allows more in‐depth studies of human parainfluenza viruses (HPIV). This study aimed to assess seasonality of HPIV types 1‐4, clinical outcomes by HPIV type, and risk factors for illness severity. This retrospective study was performed from January 2013 to December 2015 in children and adults with HPIV, detected by multiplex reverse transcription polymerase chain reaction, participating in a community surveillance study of acute respiratory infections (ARIs) in New York City and patients admitted to a tertiary care center in the same neighborhood. Seasonality trends by HPIV type were compared between the community and hospital groups. The associations between HPIV type, demographics, clinical characteristics, and illness severity were assessed. HPIV was detected in 69 (4%) of 1753 community surveillance participants (median age 9.2 years) and 680 hospitalized patients (median age 6.8 years). Seasonality for HPIV types 1‐3 agreed with previously described patterns; HPIV‐4 occurred annually in late summer and fall. In the community cohort, 22 (32%) participants sought medical care, 9 (13%) reported antibiotic use, and 20 (29%) reported ≥1 day of missed work or school. Among hospitalized patients, 24% had ≥4 chronic conditions. Multivariable ordinal logistic regression demonstrated that increased severity of illness was significantly associated with HPIV‐4 and chronic cardiovascular and respiratory conditions in children and with age ≥65 years and chronic respiratory conditions in adults. HPIV‐4 presented late summer and early fall annually and was associated with increased severity of illness in hospitalized children.
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影响因子：
11.8
作者：
Fry, Alicia M.;Curns, Aaron T.;Anderson, Larry J.
通讯作者：
Anderson, Larry J.
影响因子：
11.8
作者：
Vachon ML;Dionne N;Leblanc E;Moisan D;Bergeron MG;Boivin G
通讯作者：
Boivin G
影响因子：
12.7
作者：
Xiao, Ni-guang;Duan, Zhao-jun;Zhang, Bing
通讯作者：
Zhang, Bing
影响因子：
3.2
作者：
Abedi, Glen R.;Prill, Mila M.;Schneider, Eileen
通讯作者：
Schneider, Eileen
影响因子：
3.7
作者：
Fathima S;Simmonds K;Invik J;Scott AN;Drews S
通讯作者：
Drews S