The effects of anodal tDCS over the supplementary motor area on gait initiation in Parkinson's disease with freezing of gait: a pilot study.
The effects of anodal tDCS over the supplementary motor area on gait initiation in Parkinson's disease with freezing of gait: a pilot study.
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阳极TDC对补充运动区域的影响对帕金森氏病的步态开始，步态冻结：一项试点研究。
DOI：
10.1007/s00415-018-8953-1
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发表时间：
2018-09
影响因子：
6
通讯作者：
MacKinnon CD
中科院分区：
文献类型：
--
作者：
Lu C;Amundsen Huffmaster SL;Tuite PJ;MacKinnon CD
我们研究了在辅助运动区(SMA)上施加阳极式经颅直流电刺激(A-tDC)是否能改善伴有步态冻结(FOG)的帕金森病(PD)患者的步态启动。在这项双盲交叉试验中，10例帕金森病伴雾患者接受了两次刺激：A-tDCs(1 mA，10min)和假刺激。每次实验共收集8个步态启动区块：(1)有声学提示的tdcs前；(2)tdcs前，自启动(无提示)；(3-8)tdcs后，自启动。用双向重复测量方差分析A-tDCSs对步态启动动力学的影响。与基线措施相比，A-tdcs没有显著改善预期姿势调整的幅度或时机，也没有显著改善自主步态期间第一步的执行(p>；.13)。没有显著变化并不是因为无法产生功能性APA，因为外部提示显著改善了步态启动(p<；.01)。SMA上单次注射A-tDCs不能改善PD和FOG患者的自主步态。使用不同剂量或皮质靶点的替代方法值得探索，因为个人表现出了改善的能力。为促进SMA活动而量身定做的神经调节策略可能对帕金森病和雾患者的步态启动障碍无效。
We investigated if anodal transcranial direct current stimulation (A-tDCS), applied over the supplementary motor areas (SMAs), could improve gait initiation in Parkinson’s disease (PD) with freezing of gait (FOG). In this double-blinded cross-over pilot study, ten PD with FOG underwent two stimulation sessions: A-tDCS (1 mA, 10 min) and sham stimulation. Eight blocks of gait initiation were collected per session: (1) pre-tDCS, with acoustic cueing; (2) pre-tDCS, self-initiated (no cue); and (3–8) post-tDCS, self-initiated. Gait initiation kinetics were analyzed with two-way repeated measures ANOVAs for the effects of A-tDCS. A-tDCS did not significantly improve the magnitude or timing of anticipatory postural adjustments or the execution of the first step during self-initiated gait compared with baseline measures (p > .13). The lack of significant change was not due to an inability to generate functional APAs since external cueing markedly improved gait initiation (p < .01). A single dose of A-tDCS over the SMAs did not improve self-initiated gait in PD and FOG. Alternative approaches using a different dose or cortical target are worthy of exploration since individuals demonstrated the capacity to improve. Neuromodulation strategies tailored to facilitate SMA activity may be ineffective for the treatment of gait initiation impairment in people with PD and FOG.
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影响因子：
5.3
作者：
Jacobs, Jesse V.;Nutt, John G.;Carlson-Kuhta, Patricia;Stephens, Marilee;Horak, Fay B.
通讯作者：
Horak, Fay B.
最佳数量的脉冲数量作为神经腔内颅磁刺激的结果度量。
DOI：
10.1016/j.clinph.2016.04.001
发表时间：
2016-08
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Chang WH;Fried PJ;Saxena S;Jannati A;Gomes-Osman J;Kim YH;Pascual-Leone A
通讯作者：
Pascual-Leone A
影响因子：
4.7
作者：
Delval, Arnaud;Moreau, Caroline;Defebvre, Luc
通讯作者：
Defebvre, Luc
影响因子：
2.7
作者：
Carlsen, Anthony N.;Eagles, Jeremy S.;MacKinnon, Colum D.
通讯作者：
MacKinnon, Colum D.
影响因子：
3.5
作者：
Costa-Ribeiro, Adriana;Maux, Ariadne;Monte-Silva, Katia
通讯作者：
Monte-Silva, Katia