Reference Intervals for Bone Impact Microindentation in Healthy Adults: A Multi-Centre International Study.
Reference Intervals for Bone Impact Microindentation in Healthy Adults: A Multi-Centre International Study.
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DOI：
10.1007/s00223-022-01047-y
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发表时间：
2023-03
影响因子：
4.2
通讯作者：
Pasco, Julie A.
中科院分区：
文献类型：
--
作者：
Rufus-Membere, Pamela;Holloway-Kew, Kara L.;Diez-Perez, Adolfo;Appelman-Dijkstra, Natasha M.;Bouxsein, Mary L.;Eriksen, Erik F.;Farr, Joshua N.;Khosla, Sundeep;Kotowicz, Mark A.;Nogues, Xavier;Rubin, Mishaela;Pasco, Julie A.
关键词：
冲击微压痕（IMI）是一种用于评估体内骨材料强度指数（BMSi）的新技术，通过测量微米级球形尖端进入皮质骨的深度，然后将其索引为尖端进入参考材料的深度。本研究的目的是通过评价来自美国、欧洲和澳大利亚的健康成人来确定男性和女性的参考区间。参与者包括以社区为基础的志愿者和来自临床和以人口为基础的研究的参与者。在2011年至2018年期间，使用OsteoProbe在7个研究中心的479名健康成年人（197名男性和282名女性，年龄25至98岁）的胫骨骨干上测量了BMSi。BMSi，年龄，性别和区域骨密度（BMD）之间的关联进行了检查后验方法。无单位BMSi值范围为48至101。男性的平均（±标准差）BMSi为84.4 ± 6.9，女性为79.0 ± 9.1。BMSi的健康参考区间确定为男性71.0至97.9，女性59.8至95.2。本研究提供了健康的参考数据，可用于计算BMSi的T和Z分数，并有助于确定BMSi在裂缝预测中的实用性。这些数据将有助于在人群中定位个体，并用于识别人群极端的BMSi。
Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo, by measuring the depth of a micron-sized, spherical tip into cortical bone that is then indexed to the depth of the tip into a reference material. The aim of this study was to define the reference intervals for men and women by evaluating healthy adults from the United States of America, Europe and Australia. Participants included community-based volunteers and participants drawn from clinical and population-based studies. BMSi was measured on the tibial diaphysis using an OsteoProbe in 479 healthy adults (197 male and 282 female, ages 25 to 98 years) across seven research centres, between 2011 and 2018. Associations between BMSi, age, sex and areal bone mineral density (BMD) were examined following an a posteriori method. Unitless BMSi values ranged from 48 to 101. The mean (± standard deviation) BMSi for men was 84.4 ± 6.9 and for women, 79.0 ± 9.1. Healthy reference intervals for BMSi were identified as 71.0 to 97.9 for men and 59.8 to 95.2 for women. This study provides healthy reference data that can be used to calculate T- and Z-scores for BMSi and assist in determining the utility of BMSi in fracture prediction. These data will be useful for positioning individuals within the population and for identifying those with BMSi at the extremes of the population.
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影响因子：
5.8
作者：
Furst, Jessica R.;Bandeira, Leonardo C.;Rubin, Mishaela R.
通讯作者：
Rubin, Mishaela R.
影响因子：
1.6
作者：
Ly, Franklin S.;Proctor, Alexander;Hansma, Paul K.
通讯作者：
Hansma, Paul K.
影响因子：
5.8
作者：
Malgo, F.;Hamdy, N. A. T.;Appelman-Dijkstra, N. M.
通讯作者：
Appelman-Dijkstra, N. M.
影响因子：
4
作者：
Malgo, F.;Hamdy, N. A. T.;Appelman-Dijkstra, N. M.
通讯作者：
Appelman-Dijkstra, N. M.
影响因子：
4.1
作者：
Holloway-Kew, Kara L.;Rufus-Membere, Pamela;Pasco, Julie A.
通讯作者：
Pasco, Julie A.