Poverty and Community-Acquired Antimicrobial Resistance with Extended-Spectrum β-Lactamase-Producing Organisms, Hyderabad, India.
Poverty and Community-Acquired Antimicrobial Resistance with Extended-Spectrum β-Lactamase-Producing Organisms, Hyderabad, India.
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DOI：
10.3201/eid2408.171030
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发表时间：
2018-08
影响因子：
11.8
通讯作者：
Owens DK
中科院分区：
文献类型：
--
作者：
Alsan M;Kammili N;Lakshmi J;Xing A;Khan A;Rani M;Kolli P;Relman DA;Owens DK
抗菌药物有效性的下降是一个全球公共卫生威胁，但低收入环境中社区获得性抗菌药物耐药性（CA-AMR）的危险因素尚未明确阐明。我们的目的是确定印度城市女性中产生超广谱 β-内酰胺酶 (ESBL) 的 CA-AMR 的危险因素。我们在印度海得拉巴一家公立医院的初产妇观察性研究中收集了微生物学和调查数据。我们使用多元逻辑回归和线性回归分析数据，发现 1,836 名女性中有 7% 患有菌尿； 48% 的分离株是产 ESBL 的微生物。收入分配最低 50% 的女性更有可能患菌尿（调整后比值比 1.44，95% CI 0.99–2.10），并且更容易患产 ESBL 微生物菌尿（调整后比值比 2.04，95% CI 1.17–3.54）。非参数分析表明 ESBL 患病率与收入之间存在负相关关系。
The decreasing effectiveness of antimicrobial agents is a global public health threat, yet risk factors for community-acquired antimicrobial resistance (CA-AMR) in low-income settings have not been clearly elucidated. Our aim was to identify risk factors for CA-AMR with extended-spectrum β-lactamase (ESBL)–producing organisms among urban-dwelling women in India. We collected microbiological and survey data in an observational study of primigravidae women in a public hospital in Hyderabad, India. We analyzed the data using multivariate logistic and linear regression and found that 7% of 1,836 women had bacteriuria; 48% of isolates were ESBL-producing organisms. Women in the bottom 50th percentile of income distribution were more likely to have bacteriuria (adjusted odds ratio 1.44, 95% CI 0.99–2.10) and significantly more likely to have bacteriuria with ESBL-producing organisms (adjusted odds ratio 2.04, 95% CI 1.17–3.54). Nonparametric analyses demonstrated a negative relationship between the prevalence of ESBL and income.
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影响因子：
3.7
作者：
Bate R;Tren R;Mooney L;Hess K;Mitra B;Debroy B;Attaran A
通讯作者：
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DOI：
10.1016/0924-8579(94)00064-2
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作者：
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