High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays.
High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays.
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DOI：
10.1038/s41378-021-00298-3
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发表时间：
2021
影响因子：
7.9
通讯作者：
Davies GJ
中科院分区：
文献类型：
--
作者：
Faraji Rad Z;Prewett PD;Davies GJ
在过去的二十年里，微针贴片作为药物/疫苗输送或用于诊断和监测目的的液体采样系统受到了极大的关注。微针是使用各种加法和减法微制造技术制造的。在过去的十年里，添加剂制造技术的应用在研究和工业上都得到了很大的重视，如3D打印、熔融沉积建模、喷墨打印和双光子聚合(2PP)，其中2PP是最灵活的微针阵列制造方法。2PP是最通用和最精确的添加制造工艺之一，它可以直接从分辨率低至100 nm的计算机辅助设计模型制造任意三维(3D)原型。由于其前所未有的灵活性和高的空间分辨率，该技术已被广泛用于制造生物微器件和生物纳米器件，如微针和微流控器件。这是一项开创性的变革性技术，有助于制造复杂的微型化结构，而这些结构无法通过注塑、光刻和蚀刻等现有的多步骤制造方法制造出来。因此，微结构的设计是根据结构和流体动力学的考虑，而不是由加工或蚀刻工艺等方法施加的制造约束。本文介绍了2PP的基本原理，以及利用2PP制作微针阵列的最新进展，它是一种可以克服传统制造工艺缺点的精密而独特的微结构制造方法。
Microneedle patches have received much interest in the last two decades as drug/vaccine delivery or fluid sampling systems for diagnostic and monitoring purposes. Microneedles are manufactured using a variety of additive and subtractive micromanufacturing techniques. In the last decade, much attention has been paid to using additive manufacturing techniques in both research and industry, such as 3D printing, fused deposition modeling, inkjet printing, and two-photon polymerization (2PP), with 2PP being the most flexible method for the fabrication of microneedle arrays. 2PP is one of the most versatile and precise additive manufacturing processes, which enables the fabrication of arbitrary three-dimensional (3D) prototypes directly from computer-aided-design (CAD) models with a resolution down to 100 nm. Due to its unprecedented flexibility and high spatial resolution, the use of this technology has been widespread for the fabrication of bio-microdevices and bio-nanodevices such as microneedles and microfluidic devices. This is a pioneering transformative technology that facilitates the fabrication of complex miniaturized structures that cannot be fabricated with established multistep manufacturing methods such as injection molding, photolithography, and etching. Thus, microstructures are designed according to structural and fluid dynamics considerations rather than the manufacturing constraints imposed by methods such as machining or etching processes. This article presents the fundamentals of 2PP and the recent development of microneedle array fabrication through 2PP as a precise and unique method for the manufacture of microstructures, which may overcome the shortcomings of conventional manufacturing processes.
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DOI：
10.1016/j.jconrel.2019.11.023
发表时间：
2020-01-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Balmert SC;Carey CD;Falo GD;Sethi SK;Erdos G;Korkmaz E;Falo LD Jr
通讯作者：
Falo LD Jr
影响因子：
16.6
作者：
Gissibl T;Thiele S;Herkommer A;Giessen H
通讯作者：
Giessen H
影响因子：
6.1
作者：
Crowe, J. A.;El-Tamer, A.;Rafailov, E. U.
通讯作者：
Rafailov, E. U.
影响因子：
3.2
作者：
Deng, Yu-Luen;Juang, Yi-Je
通讯作者：
Juang, Yi-Je
影响因子：
9.7
作者：
Doraiswamy, A;Jin, C;Chichkov, B
通讯作者：
Chichkov, B