Use of photosensitising diuretics and risk of skin cancer: a population-based case-control study.
Use of photosensitising diuretics and risk of skin cancer: a population-based case-control study.
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DOI：
10.1038/sj.bjc.6604686
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发表时间：
2008-11-04
影响因子：
8.8
通讯作者：
Karagas, M. R.
中科院分区：
文献类型：
--
作者：
Jensen, A. O.;Thomsen, H. F.;Engebjerg, M. C.;Olesen, A. B.;Sorensen, H. T.;Karagas, M. R.
利尿剂具有光敏特性。然而，人们对这些利尿剂如何影响皮肤癌风险知之甚少。在丹麦的北日德兰县，我们调查了光敏性利尿剂的使用是否与发生基底细胞癌(BCC)、鳞状细胞癌(SCC)和恶性黑色素瘤(MM)的风险增加有关。从癌症登记中，我们确定了1989-2003年间的BCC、SCC和MM的原发病例。我们从丹麦民事登记系统中为每个病例选择了四个人口控制措施，年龄和性别匹配。癌症诊断前的光敏利尿剂处方是在该县的处方数据库中确定的。我们使用条件Logistic回归来计算发病率比(IRR)，控制了慢性疾病和既往口服糖皮质激素的使用。我们发现联合使用阿米洛利和氢氯噻嗪的患者患鳞癌和多发性骨髓瘤的风险增加(IRR为1.79(95%可信区间：1.45-2.21))和MM(IRR为1.43(95%CI：1.09-1.88))。吲达帕胺使用者患多发性骨髓瘤的风险增加(IRR为3.30(95%CI：1.34-8.10))。我们发现与基底细胞癌的风险几乎没有关联。我们的发现提供了证据，证明使用一些光敏性利尿剂与鳞癌和MM的风险增加有关。
Diuretics have photosensitising properties. However, little is known about how these diuretics affect the risk of skin cancers. In North Jutland County, Denmark, we investigated whether the use of photosensitising diuretics was associated with an increased risk for developing basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). From the cancer registry, we identified primary cases of BCC, SCC and MM during the period of 1989–2003. We selected four population controls for each case from the Danish Civil Registration System, matched on age and gender. Prescriptions for photosensitising diuretics before cancer diagnosis were ascertained in the county's Prescription Database. We used conditional logistic regression to compute incidence rate ratio (IRR), controlling for the chronic medical conditions and for the previous use of oral glucocorticoids. We found an increased risk of SCC (IRR of 1.79 (95% confidence interval (CI): 1.45–2.21)) and MM (IRR of 1.43 (95% CI: 1.09–1.88)) among users of combined amiloride and hydrochlorothiazide therapy. An increased risk of MM (IRR of 3.30 (95% CI: 1.34–8.10)) was found among users of indapamide. We found little associations with risk of BCC. Our findings provide evidence that the use of some photosensitising diuretics is associated with an increased risk for SCC and MM.
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DOI：
10.1111/j.1467-985x.2004.00349.x
发表时间：
2005-01-01
影响因子：
2
作者：
Greenland, S
通讯作者：
Greenland, S
影响因子：
6.5
作者：
Jensen, Annette O.;Olesen, Anne B.;Karagas, Margaret R.
通讯作者：
Karagas, Margaret R.
影响因子：
158.5
作者：
STERN, RS;LAIRD, N;BLEICH, HL
通讯作者：
BLEICH, HL
影响因子：
10.3
作者：
ADDO, HA;FERGUSON, J;FRAINBELL, W
通讯作者：
FRAINBELL, W
DOI：
10.3233/jrs-1997-10309
发表时间：
1997-01-01
期刊：
The International journal of risk & safety in medicine
影响因子：
--
作者：
Nielsen, G L;Sorensen, H T;Olsen, J
通讯作者：
Olsen, J