Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.

Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.
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DOI:
10.1016/j.ijpara.2020.05.001
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发表时间:
2020-05
影响因子:
4
通讯作者:
Boyle JP
Boyle JP
中科院分区:
医学2区
文献类型:
--
作者:
Wong ZS;Borrelli SLS;Coyne CC;Boyle JP

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刚地弓形虫在成功感染来自多个门的脊椎动物宿主的能力上是非常独特的,并且可以成功地感染这些生物体中的大多数细胞。这些物种的感染结果是由寄生虫和宿主基因型之间复杂的相互作用决定的。随着量化细胞功能全球变化的技术变得更加容易获得和精确,新的数据正在揭示i)不同宿主细胞类型对寄生虫感染的反应以及ii)不同寄生虫物种对宿主的影响。在这里,我们将重点介绍最近的研究,比较不同细胞类型对细胞内寄生的反应,并从弓形虫及其近亲的比较研究中了解宿主-寄生虫相互作用。
Toxoplasma gondii is remarkably unique in its ability to successfully infect vertebrate hosts from multiple phyla and can successfully infect most cells within these organisms. The infection outcome in each of these species is determined by the complex interaction between parasite and host genotype. As techniques to quantify global changes in cell function become more readily available and precise, new data are coming to light about how i) different host cell types respond to parasitic infection and ii) different parasite species impact the host. Here we focus on recent studies comparing the response to intracellular parasitism by different cell types and insights into understanding host-parasite interactions from comparative studies on T. gondii and its close extant relatives.
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