Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.
Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.
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DOI:
10.1016/j.ijpara.2020.05.001
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发表时间:
2020-05
影响因子:
4
通讯作者:
Boyle JP
中科院分区:
文献类型:
--
作者:
Wong ZS;Borrelli SLS;Coyne CC;Boyle JP
Toxoplasma gondii is remarkably unique in its ability to successfully infect vertebrate hosts from multiple phyla and can successfully infect most cells within these organisms. The infection outcome in each of these species is determined by the complex interaction between parasite and host genotype. As techniques to quantify global changes in cell function become more readily available and precise, new data are coming to light about how i) different host cell types respond to parasitic infection and ii) different parasite species impact the host. Here we focus on recent studies comparing the response to intracellular parasitism by different cell types and insights into understanding host-parasite interactions from comparative studies on T. gondii and its close extant relatives.
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