Prevalence, predictors, and characteristics of off-treatment fatigue in breast cancer survivors.
Prevalence, predictors, and characteristics of off-treatment fatigue in breast cancer survivors.
复制标题
DOI：
10.1002/cncr.25294
复制
发表时间：
2010-12-15
期刊：
影响因子：
6.2
通讯作者：
Jacobsen, Paul B.
中科院分区：
文献类型：
--
作者：
Andrykowski, Michael A.;Donovan, Kristine A.;Laronga, Christine;Jacobsen, Paul B.
关于如何识别明显疲劳的癌症患者缺乏共识阻碍了癌症相关疲劳（CRF）的研究。采用特定的标准来确定0-II期乳腺癌妇女的CRF病例（BC组，n = 304）。女性在辅助治疗前（基线）、辅助治疗结束后（治疗后）、辅助治疗结束后6个月和42个月（治疗后6个月和42个月）完成评估。在每个实验中，女性都完成了临床访谈和评估身心健康的问卷调查。无BC病史的健康对照（HC）组（n = 337）间隔36个月完成2次类似评估。治疗结束后6个月和42个月的CRF患病率分别为9%和13%。因此，15%的样本证明了治疗期CRF， 7%的样本证明了延迟性CRF。术后6个月评估时的CRF仅与基线时（OR = 3.2）和术后评估时（OR = 3.9）相关。术后42个月评估时的CRF与术后评估时的CRF （OR = 6.1）、基线时的肥胖以及应对疲劳的一些基线措施相关。非治疗期CRF病例与非治疗期CRF病例和健康对照者在一系列健康状况指标上存在显著差异（平均效应值bbb1.0 SD）。研究结果记录了停止治疗和延迟发作的慢性肾功能衰竭的患病率，提出了慢性肾功能衰竭认知-行为模型的实用性，并支持NCCN指南建议在整个癌症发展过程中监测疲劳。
Lack of consensus regarding how to identify cancer patients with significant fatigue has hampered research regarding cancer-related fatigue (CRF). Specific criteria were used to identify CRF cases in women with stage 0-II breast cancer (BC group, n = 304). Women completed assessments before adjuvant therapy (baseline), end of adjuvant therapy (Post-Tx), and 6 and 42 months after end of adjuvant therapy (6 and 42 Month Post-Tx). At each, women completed a clinical interview and questionnaires assessing physical and mental health. A healthy control (HC) group with no history of BC (n = 337) completed 2 similar assessments 36 months apart. Off-treatment CRF prevalence was 9% and 13% at the 6 and 42 Month Post-Tx assessments, respectively. Thus, 15% of the sample evidenced off-treatment CRF with 7% evidencing delayed onset CRF. CRF at the 6 Month Post-Tx assessment was associated only with CRF at baseline (OR = 3.2) and Post-Tx assessments (OR = 3.9). CRF at the 42 Month Post-Tx assessment was associated with CRF at the Post-Tx assessment (OR = 6.1), obesity at baseline, and several baseline measures of coping in response to fatigue. Off-treatment CRF cases differed markedly from CRF noncases and healthy controls on a spectrum of health status indices (mean effect size >1.0 SD). Results document the prevalence of off-treatment and delayed onset CRF, suggest the utility of a cognitive-behavioral model of CRF, and support NCCN guidelines recommending monitoring fatigue across the cancer trajectory.
登录
查看更多内容
影响因子：
4.2
作者：
Donovan, Kristine A.;Small, Brent J.;Jacobsen, Paul B.
通讯作者：
Jacobsen, Paul B.
影响因子：
6.2
作者：
Jacobsen, Paul B.;Donovan, Kristine A.;Andrykowski, Michael A.
通讯作者：
Andrykowski, Michael A.
影响因子：
45.3
作者：
Andrykowski, MA;Schmidt, JE;Jacobsen, PB
通讯作者：
Jacobsen, PB
DOI：
10.1046/j.1523-5394.2001.009003119.x
发表时间：
2001-05-01
期刊：
CANCER PRACTICE
影响因子：
--
作者：
Mock, V;Pickett, M;McCorkle, R
通讯作者：
McCorkle, R
影响因子：
1.2
作者：
RADLOFF L S
通讯作者：
RADLOFF L S