The impact of CNS-directed treatment on quality of life in childhood cancer survivors.
The impact of CNS-directed treatment on quality of life in childhood cancer survivors.
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DOI：
10.1007/s11136-021-02984-1
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Gerhardt CA
中科院分区：
文献类型：
--
作者：
Lipak KG;Rausch JR;Fisher RS;Prussien KV;Clark OE;Kenney AE;Himelhoch AC;Olshefski RS;Nahata L;Vannatta K;Compas BE;Gerhardt CA
Pediatric cancer survivors may have lower quality of life (QoL), but most research has assessed outcomes either in treatment or long-term survivorship. We focused on early survivorship (i.e., three and five years post-diagnosis), examining the impact of CNS-directed treatment on child QoL, as well as sex and age at diagnosis as potential moderators. Families of children with cancer (ages 5–17) were recruited at diagnosis or relapse (N=336). Survivors completed the PedsQL at three (n=96) and five (n=108) years, along with mothers (101 & 105, respectively) and fathers (45 & 53, respectively). The impact of CNS treatment, sex, and age at diagnosis on child QoL was examined over both time since diagnosis and time since last treatment using mixed model analyses. Parent-report of the child’s total QoL was in the normative range and stable between three and five years when examining time since diagnosis, while child reported QoL improved over time (p=0.04). In terms of time since last treatment, mother and child both reported the child’s QoL improved over time (p=0.0002 and p=0.0006, respectively). Based on parent-report, males with CNS-directed treatment had lower total QoL than females and males who did not receive CNS-directed treatment. Age at diagnosis did not moderate the impact of treatment type on total QoL. QoL in early survivorship may be low among males who received CNS-directed treatment. However, this was only evident on parent-report. Interventions to improve child QoL should focus on male survivors who received CNS-directed treatment, as well as females regardless of treatment type.
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