Optimal Temporal Resolution to Achieve Good Image Quality and Perform Pharmacokinetic Analysis in Free-breathing Dynamic Contrast-enhanced MR Imaging of the Pancreas.
Optimal Temporal Resolution to Achieve Good Image Quality and Perform Pharmacokinetic Analysis in Free-breathing Dynamic Contrast-enhanced MR Imaging of the Pancreas.
复制标题
DOI：
10.2463/mrms.mp.2022-0035
复制
发表时间：
2023-10-01
影响因子：
3
通讯作者：
Fujinaga, Yasunari
中科院分区：
文献类型：
--
作者：
Oyama, Kazuki;Ichinohe, Fumihito;Yamada, Akira;Kitoh, Yoshihiro;Adachi, Yasuo;Hayashihara, Hayato;Nickel, Marcel D.;Maruyama, Katsuya;Fujinaga, Yasunari
关键词：
目的：胰腺自由呼吸动态增强MRI（FBDCE-MRI）的最佳时间分辨率尚未确定。本研究旨在评价适当的时间分辨率，以实现良好的图像质量，并使用黄金角径向稀疏平行（GRASP）在胰腺FBDCE-MRI中进行药代动力学分析。方法：本前瞻性研究纳入了16名接受FBDCE-MRI的受试者（53 ± 15岁，8名女性）。以四种时间分辨率（1.8、3.0、4.8和7.8s）回顾性重建图像。两名放射科医生（5年经验）通过使用5分制评估腹腔动脉（CEA）、肝总动脉、脾动脉、胰腺每个区域和伪影的可视化来评价每个重建图像的图像质量。使用Tissue-4D，计算了16次检查的每个时间分辨率下重建图像中每个区域的药代动力学参数，排除了药代动力学建模分析中存在错误的两次检查。Friedman和Bonferroni检验用于分析。P值< 0.05为有统计学意义。结果：在血管评估过程中，只有CEA在7.8s时的评分显著低于其他时间分辨率。所有胰腺区域和伪影的评分在1.8s时显著低于4.8s和7.8s时。在药代动力学分析中，4.8 s和7.8 s时胰头和胰尾的所有体积传递系数（Ktranss）、速率常数（Kep）和初始浓度曲线下面积（iAUC）均显著低于1.8 s时。胰体中的iAUC和胰头中的细胞外血管外体积分数（Ve）在7.8s时显著低于1.8s时。结论：3.0 s的时间分辨率适用于实现图像质量并使用GRASP在胰腺的FBDCE-MRI中进行药代动力学分析。
Purpose: The optimal temporal resolution for free-breathing dynamic contrast-enhanced MRI (FBDCE-MRI) of the pancreas has not been determined. This study aimed to evaluate the appropriate temporal resolution to achieve good image quality and to perform pharmacokinetic analysis in FBDCE-MRI of the pancreas using golden-angle radial sparse parallel (GRASP). Methods: Sixteen participants (53 ± 15 years, eight females) undergoing FBDCE-MRI were included in this prospective study. Images were retrospectively reconstructed at four temporal resolutions (1.8, 3.0, 4.8, and 7.8s). Two radiologists (5 years of experience) evaluated the image quality of each reconstructed image by assessing the visualization of the celiac artery (CEA), the common hepatic artery, the splenic artery, each area of the pancreas, and artifacts using a 5-point scale. Using Tissue-4D, pharmacokinetic parameters were calculated for each area in the reconstructed images at each temporal resolution for 16 examinations, excluding two with errors in the pharmacokinetic modeling analysis. Friedman and Bonferroni tests were used for analysis. A P value < 0.05 was considered statistically significant. Results: During vascular assessment, only scores for the CEA at 7.8s were significantly lower than the other temporal resolutions. Scores of all pancreatic regions and artifacts were significantly lower at 1.8s than at 4.8s and 7.8s. In the pharmacokinetic analysis, all volume transfer coefficients (Ktrans), rate constants (Kep), and the initial area under the concentration curve (iAUC) in the pancreatic head and tail were significantly lower at 4.8s and 7.8s than at 1.8s. iAUC in the pancreatic body and extracellular extravascular volume fraction (Ve) in the pancreatic head were significantly lower at 7.8s than at 1.8s. Conclusion: A temporal resolution of 3.0s is appropriate to achieve image quality and perform pharmacokinetic analysis in FBDCE-MRI of the pancreas using GRASP.
登录
查看更多内容
影响因子：
5.9
作者：
Fujinaga, Yasunari;Ohya, Ayumi;Kadoya, Masumi
通讯作者：
Kadoya, Masumi
影响因子：
10.6
作者：
Winkelmann, Stefanie;Schaeffter, Tobias;Doessel, Olaf
通讯作者：
Doessel, Olaf
影响因子：
4.4
作者：
Lecler, Augustin;Balvay, Daniel;Fournier, Laure
通讯作者：
Fournier, Laure
影响因子：
6.7
作者：
Othman, Ahmed E.;Falkner, Florian;Notohamiprodjo, Mike
通讯作者：
Notohamiprodjo, Mike
影响因子：
19.7
作者：
Akisik, M. Fatih;Sandrasegaran, Kumaresan;Chiorean, Elena G.
通讯作者：
Chiorean, Elena G.