Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters.
Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters.
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DOI：
10.1016/j.antiviral.2013.10.012
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发表时间：
2014-01
影响因子：
7.6
通讯作者：
Spiropoulou, Christina F.
中科院分区：
文献类型：
--
作者：
Lo, Michael K.;Bird, Brian H.;Chattopadhyay, Anasuya;Drew, Clifton P.;Martin, Brock E.;Coleman, Joann D.;Rose, John K.;Nichol, Stuart T.;Spiropoulou, Christina F.
Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans.
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