Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis.
Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis.
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CST1 表达升高会促进乳腺癌进展并预测不良预后。
DOI：
10.1007/s00109-017-1537-1
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Wei WD
中科院分区：
文献类型：
--
作者：
Dai DN;Li Y;Chen B;Du Y;Li SB;Lu SX;Zhao ZP;Zhou AJ;Xue N;Xia TL;Zeng MS;Zhong Q;Wei WD
胱抑素SN(CST1)属于第二型胱抑素(CST)超家族，限制半胱氨酸蛋白酶的蛋白分解活性。CST1最近被认为与几种人类癌症的发生有关。然而，CST1在乳腺癌中的预后意义和功能仍不清楚。在目前的研究中，我们发现CST1在乳腺癌中普遍在mRNA和蛋白水平上表达。此外，Cst1低表达亚组的总生存期(OS)和无病生存期(DFS)明显优于Cst1高表达亚组(OS，P<0.001；DFS，P<0.001)，表明CST_1表达水平与患者的生存风险密切相关。单因素和多因素分析显示，CST1的表达是独立的预后因素，与ER状态和淋巴结状态相同。其次，CST1的过表达促进了乳腺癌细胞的增殖、克隆形成、迁移和侵袭能力。相比之下，CST1基因的敲除减弱了乳腺癌细胞的这些恶性特征。总之，我们的研究表明，CST1不仅可以作为一个重要的预后指标，而且还可以作为乳腺癌的潜在治疗靶点。CST1的高表达与乳腺癌患者的生存呈负相关。CST1促进乳腺癌细胞的增殖、克隆形成和转移。CST1是一种新的潜在的乳腺癌预后生物标志物和治疗靶点。本文的在线版本(doi：10.1007/s00109-017-1537-1)包含补充材料，授权用户可以使用。
Cystatin SN (CST1) belongs to the type 2 cystatin (CST) superfamily, which restricts the proteolytic activities of cysteine proteases. CST1 has been recently considered to be involved in the development of several human cancers. However, the prognostic significance and function of CST1 in breast cancer remains unknown. In the current study, we found that CST1 was generally upregulated in breast cancer at both mRNA and protein level. Furthermore, overall survival (OS) and disease-free survival (DFS) in the low CST1 expression subgroup were significantly superior to the high CST1 expression subgroup (OS, p < 0.001; DFS, p < 0.001), which indicated that CST1 expression level was closely correlated to the survival risk of these patients. Univariate and multivariate analyses demonstrated that CST1 expression was an independent prognostic factor, the same as ER status and nodal status. Next, CST1 overexpression promoted breast cancer cell proliferation, clonogenicity, migration, and invasion abilities. By contrast, knockdown of CST1 attenuated these malignant characteristics in breast cancer cells. Collectively, our study indicates that CST1 cannot only serve as a significant prognostic indicator but also as a potential therapeutic target for breast cancer. High CST1 expression is negatively correlated with survival of breast cancer patients. CST1 promotes cell proliferation, clone formation, and metastasis in breast cancer cells. CST1 is a novel potential prognostic biomarker and therapeutic target for breast cancer. The online version of this article (doi:10.1007/s00109-017-1537-1) contains supplementary material, which is available to authorized users.
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影响因子：
3.7
作者：
Imoto Y;Tokunaga T;Matsumoto Y;Hamada Y;Ono M;Yamada T;Ito Y;Arinami T;Okano M;Noguchi E;Fujieda S
通讯作者：
Fujieda S
影响因子：
3.8
作者：
Bergen ES;Tichy C;Berghoff AS;Rudas M;Dubsky P;Bago-Horvath Z;Mader RM;Exner R;Gnant M;Zielinski CC;Steger GG;Preusser M;Bartsch R
通讯作者：
Bartsch R
影响因子：
3.6
作者：
MCCLISH, DK
通讯作者：
MCCLISH, DK
影响因子：
5
作者：
Choi, Eun Hwa;Kim, Jong-Tae;Lee, Hee Gu
通讯作者：
Lee, Hee Gu
Cystatin SN 的表达与手术切除的非小细胞肺癌患者的复发、转移和生存时间显着相关
影响因子：
4.6
作者：
Cao X;Li Y;Luo RZ;Zhang L;Zhang SL;Zeng J;Han YJ;Wen ZS
通讯作者：
Wen ZS