Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms.
Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms.
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转录因子Bcl - 6通过其在B细胞和T细胞中的作用协调生发中心反应，并调节巨噬细胞中的炎症信号传导。我们报道，由不能使其BTB结构域结合辅阻遏物的突变型Bcl - 6进行的基因替换，由于B细胞增殖和存活存在缺陷，破坏了生发中心的形成以及免疫球蛋白亲和力的成熟。相比之下，BTB功能缺失对T滤泡辅助细胞的分化和功能以及其他T辅助细胞亚群没有影响。Bcl6基因敲除小鼠表现出致命的炎症表型，而BTB突变小鼠正常健康生活，没有炎症。因此，Bcl - 6对巨噬细胞炎症反应的抑制作用与BTB结构域的阻遏功能无关。Bcl - 6因此通过细胞谱系特异性的生化功能来介导其作用。
The transcription factor Bcl-6 orchestrates the germinal center reaction through its actions in B and T cells, and regulates inflammatory signaling in macrophages. We report that genetic replacement by mutant Bcl-6, which cannot bind corepressors to its BTB domain, disrupted germinal center formation and immunoglobulin affinity maturation, due to a defect in B cell proliferation and survival. In contrast, BTB loss of function had no effect on T follicular helper cell differentiation and function, nor other T helper subsets. Bcl6 null mice displayed a lethal inflammatory phenotype, whereas BTB mutant mice experienced normal healthy lives with no inflammation. Bcl-6 repression of inflammatory responses in macrophages was accordingly independent of the BTB domain repressor function. Bcl-6 thus mediates its actions through lineage-specific biochemical functions.
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影响因子：
29
作者：
Barish GD;Yu RT;Karunasiri MS;Becerra D;Kim J;Tseng TW;Tai LJ;Leblanc M;Diehl C;Cerchietti L;Miller YI;Witztum JL;Melnick AM;Dent AL;Tangirala RK;Evans RM
通讯作者：
Evans RM
影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
影响因子：
2.6
作者：
Goteri, Gaia;Lucarini, Guendalina;Leoni, Pietro
通讯作者：
Leoni, Pietro
影响因子：
20.3
作者：
Basso, Katia;Saito, Masumichi;Dalla-Favera, Riccardo
通讯作者：
Dalla-Favera, Riccardo
影响因子：
30.8
作者：
Bereshchenko, OR;Gu, W;Dalla-Favera, R
通讯作者：
Dalla-Favera, R