Tessellated permanent magnet circuits for flow-through, open gradient separations of weakly magnetic materials.
Tessellated permanent magnet circuits for flow-through, open gradient separations of weakly magnetic materials.
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DOI：
10.1016/j.jmmm.2016.11.027
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发表时间：
2017-04-01
影响因子：
2.7
通讯作者：
Zborowski M
中科院分区：
文献类型：
--
作者：
Moore LR;Williams PS;Chalmers JJ;Zborowski M
新兴的基于微流体的细胞测定有利于无标记红细胞（RBC）消耗。红细胞的磁分离是可能的，因为脱氧血红蛋白的顺磁性，但该过程是缓慢的开放梯度场配置。为了提高通量，考虑了单元磁体的周期性安排，包括市售的Nd-Fe-B永磁体和软钢熔剂回流片。该磁体设计特别适合通过磁体镶嵌进行多路复用，这里的意思是通过周期性重复磁体和流道形状来平铺磁体组件横截面平面。磁体磁化的周期性模式允许每个通道磁性材料的减少，磁体孔径内的场圆柱对称的最小畸变。研究了许多这样的磁铁模式的分离器性能、尺寸和经济性，目的是设计一种开放梯度磁分离器，能够在每小时1毫升全血中降低100倍的红细胞数量浓度。
Emerging microfluidic-based cell assays favor label-free red blood cell (RBC) depletion. Magnetic separation of RBC is possible because of the paramagnetism of deoxygenated hemoglobin but the process is slow for open-gradient field configurations. In order to increase the throughput, periodic arrangements of the unit magnets were considered, consisting of commercially available Nd-Fe-B permanent magnets and soft steel flux return pieces. The magnet design is uniquely suitable for multiplexing by magnet tessellation, here meaning the tiling of the magnet assembly cross-sectional plane by periodic repetition of the magnet and the flow channel shapes. The periodic pattern of magnet magnetizations allows a reduction of the magnetic material per channel with minimal distortion of the field cylindrical symmetry inside the magnet apertures. A number of such magnet patterns are investigated for separator performance, size and economy with the goal of designing an open-gradient magnetic separator capable of reducing the RBC number concentration a hundred-fold in 1 mL whole blood per hour.
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影响因子：
14.8
作者：
通讯作者：
--
影响因子：
2.1
作者：
Moore LR;Nehl F;Dorn J;Chalmers JJ;Zborowski M
通讯作者：
Zborowski M
影响因子：
3.5
作者：
Chen, Haitao;Bockenfeld, Danny;Rosengart, Axel J.
通讯作者：
Rosengart, Axel J.
影响因子：
3.4
作者：
Furlani, E. P.
通讯作者：
Furlani, E. P.
DOI：
10.1073/pnas.22.4.210
发表时间：
1936-01-01
影响因子：
11.1
作者：
Pauling, L;Coryell, CD
通讯作者：
Coryell, CD