Concise review: evidence for CD34 as a common marker for diverse progenitors.
Concise review: evidence for CD34 as a common marker for diverse progenitors.
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DOI：
10.1002/stem.1661
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发表时间：
2014-06
期刊：
影响因子：
5.2
通讯作者：
Hopkinson, Andrew
中科院分区：
文献类型：
--
作者：
Sidney, Laura E.;Branch, Matthew J.;Dunphy, Siobhan E.;Dua, Harminder S.;Hopkinson, Andrew
CD34是一种跨膜磷酸糖蛋白，最早发现于造血干/祖细胞。临床上，它与骨髓移植中造血干细胞的选择和浓缩有关。由于这些历史和临床的相关性，CD34的表达几乎无处不在地与造血细胞有关，人们普遍误解非造血样本中的CD34阳性(CD34+)细胞代表造血污染。流行的学派认为，多能间充质基质细胞(MSC)不表达CD34。然而，强有力的证据表明，CD34不仅在MSC中表达，而且在许多其他非造血细胞类型中也有表达，包括肌肉卫星细胞、角膜基质细胞、间质细胞、上皮祖细胞和血管内皮祖细胞。在许多情况下，CD34+细胞只占总细胞群的一小部分，也表明具有增强的祖细胞活性的细胞亚群。在这里，我们探索了表达CD34的细胞之间的共同特征，包括相关的标记、形态和分化潜力。我们努力强调CD34+细胞之间的关键相似之处，重点放在祖细胞活性上。CD34的一个共同功能尚未阐明，但通过分析和了解CD34+细胞之间的联系，我们希望能够提供对表达CD34的细胞的重叠特性的洞察。干细胞2014；32：1380-1389
CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical and clinical associations, CD34 expression is almost ubiquitously related to hematopoietic cells, and it is a common misconception that CD34-positive (CD34+) cells in nonhematopoietic samples represent hematopoietic contamination. The prevailing school of thought states that multipotent mesenchymal stromal cells (MSC) do not express CD34. However, strong evidence demonstrates CD34 is expressed not only by MSC but by a multitude of other nonhematopoietic cell types including muscle satellite cells, corneal keratocytes, interstitial cells, epithelial progenitors, and vascular endothelial progenitors. In many cases, the CD34+ cells represent a small proportion of the total cell population and also indicate a distinct subset of cells with enhanced progenitor activity. Herein, we explore common traits between cells that express CD34, including associated markers, morphology and differentiation potential. We endeavor to highlight key similarities between CD34+ cells, with a focus on progenitor activity. A common function of CD34 has yet to be elucidated, but by analyzing and understanding links between CD34+ cells, we hope to be able to offer an insight into the overlapping properties of cells that express CD34. Stem Cells 2014;32:1380–1389
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DOI：
10.1016/j.biocel.2009.12.011
发表时间：
2010-05
影响因子：
4
作者：
Choi, Young H.;Burdick, Marie D.;Strieter, Robert M.
通讯作者：
Strieter, Robert M.
DOI：
10.1158/1078-0432.ccr-11-0179
发表时间：
2011-12-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
Banh A;Xiao N;Cao H;Chen CH;Kuo P;Krakow T;Bavan B;Khong B;Yao M;Ha C;Kaplan MJ;Sirjani D;Jensen K;Kong CS;Mochly-Rosen D;Koong AC;Le QT
通讯作者：
Le QT
影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
DOI：
10.1073/pnas.0501263102
发表时间：
2005-04-12
影响因子：
11.1
作者：
Amoh, Y;Li, L;Hoffman, RM
通讯作者：
Hoffman, RM
影响因子：
32.4
作者：
Drew, E;Merzaban, JS;McNagny, KM
通讯作者：
McNagny, KM