Circadian regulation of innate immunity in animals and humans and implications for human disease.

Circadian regulation of innate immunity in animals and humans and implications for human disease.
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DOI:
10.1007/s00281-022-00921-z
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发表时间:
2022-03
影响因子:
9
通讯作者:
Kitchen GB
Kitchen GB
中科院分区:
医学1区
文献类型:
--
作者:
Poole J;Kitchen GB

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昼夜节律是由核心生物钟产生的生理学中的24小时振荡变化。现在有大量的证据表明免疫系统的昼夜节律调节。先天免疫细胞包含分子生物钟,其驱动有节奏的反应,从炎症反应的大小到一天中变化的循环免疫细胞的数量。这导致疾病在临床上的节律性表现,例如夜间哮喘的经典表现或急性心肌梗死在早晨的第一件事中突然发展为肺水肿。
Circadian rhythms are 24-h oscillating variations in physiology generated by the core circadian clock. There is now a wide body of evidence showing circadian regulation of the immune system. Innate immune cells contain the molecular circadian clock which drives rhythmic responses, from the magnitude of the inflammatory response to the numbers of circulating immune cells varying throughout the day. This leads to rhythmic presentation of disease clinically, for example the classic presentation of nocturnal asthma or the sudden development of pulmonary oedema from acute myocardial infarction first thing in the morning.
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