The statistical neuroanatomy of frontal networks in the macaque.
The statistical neuroanatomy of frontal networks in the macaque.
复制标题
猕猴额叶网络的统计神经解剖学。
DOI：
10.1371/journal.pcbi.1000050
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发表时间：
2008-04-04
影响因子：
4.3
通讯作者：
Seo, Moonsang
中科院分区：
文献类型：
--
作者：
Averbeck, Bruno B.;Seo, Moonsang
我们感兴趣的是深入了解基于解剖输入的额叶网络的功能特性。我们采取了神经信息学的方法，进行最大似然分层聚类分析的25个额叶皮质区的基础上，他们的解剖连接，与68个输入区域代表外感觉，化学感觉，运动，边缘系统，和其他额叶输入。分析揭示了一组统计上稳健的聚类。我们使用这些聚类将额区分为5组，包括腹外侧、腹内侧、背内侧、背外侧和尾眶组。这些组中的每一个都由一组唯一的输入定义。这种组织提供了洞察每组区域的不同作用，并提出了一个梯度，其中眶区和腹内侧区可能负责基于情感和主要决策者的决策过程，而外侧额叶区则更多地参与将情感和理性信息整合到一个共同的框架中。对皮质区域的解剖学输入在很大程度上定义了该区域可以执行的功能。例如，如果一个区域没有视觉输入，它就不能对视觉信息进行计算。因此，了解对一片皮层的输入可以提供对该区域功能的基本了解。在猕猴中的解剖追踪研究已经定义了猕猴大脑区域之间的连接。我们汇编了25 cytoarchitectonically定义的额叶皮质区的解剖输入的信息。在其原始形式中，这种连接是非常复杂的，并且无法清楚地看到每个区域的主要输入。为了降低复杂性，我们进行了层次聚类分析的基础上，他们的输入领域。我们发现了一个统计学上很强的区域组织。所识别的集群对应于解剖学上连续的组，包括眼眶、腹内侧、背内侧、腹外侧和背外侧区域。使用这些组，我们能够清楚地定义每个集群的主要输入。我们发现，腹外侧，腹内侧，背内侧，背外侧，和尾眶组定义的外部感觉，边缘，电机，外部感觉，和化学感觉输入，分别。这些输入可能驱动每个区域中的生理反应。
We were interested in gaining insight into the functional properties of frontal networks based upon their anatomical inputs. We took a neuroinformatics approach, carrying out maximum likelihood hierarchical cluster analysis on 25 frontal cortical areas based upon their anatomical connections, with 68 input areas representing exterosensory, chemosensory, motor, limbic, and other frontal inputs. The analysis revealed a set of statistically robust clusters. We used these clusters to divide the frontal areas into 5 groups, including ventral-lateral, ventral-medial, dorsal-medial, dorsal-lateral, and caudal-orbital groups. Each of these groups was defined by a unique set of inputs. This organization provides insight into the differential roles of each group of areas and suggests a gradient by which orbital and ventral-medial areas may be responsible for decision-making processes based on emotion and primary reinforcers, and lateral frontal areas are more involved in integrating affective and rational information into a common framework. The anatomical input to a cortical area defines, to a large extent, the functions that the area can perform. For example, if an area has no visual inputs, it cannot carry out computations on visual information. Therefore, understanding the inputs to a patch of cortex can provide fundamental insight into the function of the area. Anatomical tract tracing studies in macaque monkeys have defined much of the connectivity between areas of the macaque brain. We compiled the information on the anatomical inputs to 25 cytoarchitectonically defined frontal cortical areas. In its raw form, this connectivity is immensely complex, and the dominant inputs to each area cannot be clearly seen. To reduce the complexity, we carried out hierarchical cluster analysis on the areas based upon their inputs. We found a statistically robust organization of the areas. Identified clusters corresponded to anatomically contiguous groups, including orbital, ventral-medial, dorsal-medial, ventral-lateral, and dorsal-lateral areas. Using these groups, we were able to clearly define the dominant inputs to each cluster. We found that ventral-lateral, ventral-medial, dorsal-medial, dorsal-lateral, and caudal-orbital groups were defined by exterosensory, limbic, motor, exterosensory, and chemosensory inputs, respectively. These inputs likely drive the physiological responses found in each area.
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影响因子：
56.9
作者：
Ito, S;Stuphorn, V;Schall, JD
通讯作者：
Schall, JD
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
DOI：
10.1126/science.1128356
发表时间：
2006-08-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
De Martino B;Kumaran D;Seymour B;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
2.9
作者：
ARNSTEN, AFT;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS
影响因子：
56.9
作者：
Bechara, A;Damasio, H;Damasio, AR
通讯作者：
Damasio, AR