Neural representation of pitch salience in the human brainstem revealed by psychophysical and electrophysiological indices.
Neural representation of pitch salience in the human brainstem revealed by psychophysical and electrophysiological indices.
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DOI：
10.1016/j.heares.2010.04.016
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发表时间：
2010-09-01
期刊：
影响因子：
2.8
通讯作者：
Gandour, Jackson T.
中科院分区：
文献类型：
--
作者：
Krishnan, Ananthanarayan;Bidelman, Gavin M.;Gandour, Jackson T.
在声学上，音高与声音的时间规律性或周期性有关。知觉和电生理研究表明，音调显著性随着刺激周期的增加而系统地增长。本研究的目的是表明，相关的信息音高的显着性已经编码在脑干神经元的相位锁定的神经活动，以证明音高显着性的神经表现出现皮质参与之前。脑干频率以下的反应（FFR）记录从参与者在响应语言的音调，这只在他们的音高显着程度的变化。使用自相关算法从FFR计算神经音高强度。此外，行为频率差阈值（F0 DLs）从每个参与者进行测量，以获得与音高显著性相关的感知估计。脑干神经音高强度系统地增加刺激周期性的时间规律性，表明更强大的编码显着的音高。F0的DLs下降，增加刺激周期揭示更好的音高变化检测更显着的刺激。FFR神经音高强度和行为F0 DL呈负相关，这表明皮层下处理可以部分预测个体的音高显著性行为判断。这些数据意味着，刺激的声学周期性的变化直接影响脑干编码和相应的行为反应音高。我们推断与音高显著性相关的信息可能在听觉通路的早期沿着出现，并且可能植根于前注意的感觉水平处理。
Acoustically, pitch is related to the temporal regularity or periodicity of a sound. Perceptual and electrophysiologic studies have revealed that pitch salience grows systematically with increasing stimulus periodicity. The aim of this study is to show that information relevant to pitch salience is already encoded in the phase-locked neural activity of brainstem neurons in order to demonstrate that the neural manifestation of pitch salience emerges well before cortical involvement. Brainstem frequency following responses (FFRs) were recorded from participants in response to linguistic tones, which varied only in their degree of pitch salience. Neural pitch strength was computed from FFRs using autocorrelation algorithms. In addition, behavioral frequency difference limens (F0 DLs) were measured from each participant to obtain a perceptual estimate related to pitch salience. Brainstem neural pitch strength increased systematically with increasing temporal regularity in stimulus periodicity, indicating more robust encoding for salient pitch. F0 DLs decreased with increasing stimulus periodicity revealing better pitch change detection for more salient stimuli. FFR neural pitch strength and behavioral F0 DLs were negatively correlated suggesting that subcortical processing can, in part, predict an individual’s behavioral judgments of pitch salience. These data imply that changes to the acoustic periodicity of a stimulus directly influence brainstem encoding and the corresponding behavioral responses to pitch. We infer that information related to pitch salience may emerge early along the auditory pathway and is likely rooted in pre-attentive, sensory-level processing.
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