Development of a mind body program for obese knee osteoarthritis patients with comorbid depression.
Development of a mind body program for obese knee osteoarthritis patients with comorbid depression.
复制标题
为肥胖的膝盖骨关节炎患者的合并症抑郁症患者的心理身体计划的开发。
DOI：
10.1016/j.conctc.2021.100720
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发表时间：
2021-03
影响因子：
1.5
通讯作者：
Vranceanu AM
中科院分区：
文献类型：
--
作者：
Jacobs CA;Mace RA;Greenberg J;Popok PJ;Reichman M;Lattermann C;Burris JL;Macklin EA;Vranceanu AM
膝骨性关节炎(OA)是美国最常见的关节疾病，也是导致残疾的主要原因。在膝骨性关节炎患者中，抑郁和肥胖是高度共存的，肥胖和抑郁的组合与体力活动减少、更高的疼痛和残疾以及更快的软骨退化有关。抑郁症、肥胖症和骨性关节炎相互加剧，并具有共同的病理生理机制，涉及全身炎症和促炎细胞因子，反映了复杂的身心相互作用。目前膝骨性关节炎的治疗方法比安慰剂提供的益处很少甚至没有，并且不强调针对潜在的病理生理学的身心练习或体力活动。减轻抑郁症状和增加体力活动的心身干预提供了针对OA进展的生物、机械和心理机制的能力。我们的长期目标是评估通过安全远程保健提供的、适用于抑郁症、肥胖症和膝盖骨关节炎患者的放松反应弹性计划(3RP)促进身体活动和改善膝关节健康的机制。我们假设GetActive-OA的正念、适应性思维、积极心理和健康生活技能之间的协同作用将通过减少促炎细胞因子的表达和促进软骨的最佳机械负荷来减缓症状性膝关节骨性关节炎的进展。在这里，我们提出了一项混合方法研究的方案，该方案将使3RP适应患有抑郁和肥胖的膝骨性关节炎患者的需求，重点是增加体力活动(GetActive-OA)，并反复最大化方案和研究程序的可行性、可信度和可接受性。抑郁症、肥胖症和膝骨性关节炎(OA)相互加重，具有共同的病理生理。治疗并不强调以增加体力活动为目标的身心练习，而是针对潜在的病理生理学。我们的目标是使GetActive适应患有抑郁症和肥胖症的膝骨性关节炎患者的需求。GetActive-OA计划的互联网交付绕过了许多护理障碍。
Knee osteoarthritis (OA) is the most common joint disorder in the U.S. and a leading cause of disability. Depression and obesity are highly comorbid among knee OA patients, and the combination of obesity and depression is associated with decreased physical activity, higher pain and disability, and more rapid cartilage degradation. Depression, obesity and OA exacerbate one another and share a common pathophysiology involving systemic inflammation and pro-inflammatory cytokines, reflecting a complex mind-body interaction. Current treatments for knee OA offer little to no benefit over placebo, and do not emphasize mind-body practices or physical activity to target the underlying pathophysiology. Mind-body interventions to lessen depressive symptoms and increase physical activity offer the ability to target biological, mechanical and psychological mechanisms of OA progression. Our long-term goals are to evaluate the mechanisms by which the Relaxation Response Resiliency Program (3RP) delivered via secure telehealth, and adapted for patients with depression, obesity and knee OA (GetActive-OA) promotes increases in physical activity and improved knee health. We hypothesize that the synergistic interaction between mindfulness, adaptive thinking, positive psychology and healthy living skills of the GetActive-OA will slow the progression of symptomatic knee OA by reducing pro-inflammatory cytokine expression and promoting optimal mechanical loading of the cartilage. Here we present the protocol for a mixed methods study that will adapt the 3RP for the needs of knee OA patients with depression and obesity with a focus on increasing physical activity (GetActive-OA), and iteratively maximize the feasibility, credibility and acceptability of the programs and research procedures. Depression, obesity and knee osteoarthritis (OA) exacerbate one another and share a common pathophysiology. Treatments do not emphasize mind-body practices to increase physical activity to target the underlying pathophysiology. We aim to adapt the GetActive for the needs of knee OA patients with depression and obesity. Internet delivery of the GetActive-OA program bypasses many barriers to care.
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影响因子：
5.2
作者：
Black DS;Slavich GM
通讯作者：
Slavich GM
DOI：
10.1016/j.berh.2015.04.022
发表时间：
2015-02
期刊：
Best practice & research. Clinical rheumatology
影响因子：
--
作者：
Ambrose KR;Golightly YM
通讯作者：
Golightly YM
影响因子：
5.5
作者：
Desmeules, Francois;Dionne, Clermont E.;Fremont, Pierre
通讯作者：
Fremont, Pierre
影响因子：
4.2
作者：
Czajkowski, Susan M.;Powell, Lynda H.;Charlson, Mary E.
通讯作者：
Charlson, Mary E.
影响因子：
6.1
作者：
Brand, Emily;Nyland, John;McGinnis, Mark
通讯作者：
McGinnis, Mark