Age- and sex-dependent effects of early life stress on hippocampal neurogenesis.
Age- and sex-dependent effects of early life stress on hippocampal neurogenesis.
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DOI：
10.3389/fendo.2014.00013
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发表时间：
2014
影响因子：
5.2
通讯作者：
Joëls M
中科院分区：
文献类型：
--
作者：
Loi M;Koricka S;Lucassen PJ;Joëls M
在遗传易感个体中，早期生活压力是一个充分证明的精神病理发展的危险因素。由于很难研究早期生活压力对人类大脑结构和功能的影响，人们开发了各种动物模型来解决这个问题。本文讨论的模型揭示了啮齿动物的围产期应激对应激系统以及大脑的结构和功能产生持久的影响。受围产期应激强烈影响的结构参数之一是成年海马神经发生。根据汇编的文献数据，我们报告了出生后应激在雄性大鼠青春期前轻微促进神经发生；当动物成年后，由于围产期压力，神经发生减少。相比之下，雌性大鼠在青春期前的神经发生明显减少，但当动物进入成年期后，这种影响就减弱了。我们进一步提供了初步数据，糖皮质激素受体拮抗剂的短暂治疗可以使母体剥夺的雌性大鼠的细胞增殖正常化，而该化合物对未剥夺的大鼠没有影响。综上所述，这些数据表明，早期生活压力对神经发生的影响与年龄和性别有关，而在大脑发育的关键阶段，这种影响可能会正常化。
Early life stress is a well-documented risk factor for the development of psychopathology in genetically predisposed individuals. As it is hard to study how early life stress impacts human brain structure and function, various animal models have been developed to address this issue. The models discussed here reveal that perinatal stress in rodents exerts lasting effects on the stress system as well as on the structure and function of the brain. One of the structural parameters strongly affected by perinatal stress is adult hippocampal neurogenesis. Based on compiled literature data, we report that postnatal stress slightly enhances neurogenesis until the onset of puberty in male rats; when animals reach adulthood, neurogenesis is reduced as a consequence of perinatal stress. By contrast, female rats show a prominent reduction in neurogenesis prior to the onset of puberty, but this effect subsides when animals reach young adulthood. We further present preliminary data that transient treatment with a glucocorticoid receptor antagonist can normalize cell proliferation in maternally deprived female rats, while the compound had no effect in non-deprived rats. Taken together, the data show that neurogenesis is affected by early life stress in an age- and sex-dependent manner and that normalization may be possible during critical stages of brain development.
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影响因子：
11
作者：
Anacker, C.;Zunszain, P. A.;Cattaneo, A.;Carvalho, L. A.;Garabedian, M. J.;Thuret, S.;Price, J.;Pariante, C. M.
通讯作者：
Pariante, C. M.
影响因子：
10.6
作者：
Bagot, Rosemary C.;Tse, Yiu Chung;Wong, Tak Pan
通讯作者：
Wong, Tak Pan
影响因子：
10.6
作者：
Heim, C;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
1.9
作者：
Champagne, Frances A.
通讯作者：
Champagne, Frances A.
影响因子：
7.4
作者：
Handa RJ;Weiser MJ
通讯作者：
Weiser MJ