Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms.
Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms.
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研究星形素的总类黄酮对动脉粥样硬化形成和潜在机制的影响。
DOI：
10.1155/2012/282383
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发表时间：
2012
影响因子：
--
通讯作者：
Tomlinson B
中科院分区：
文献类型：
--
作者：
Wang D;Zhuang Y;Tian Y;Thomas GN;Ying M;Tomlinson B
蒙古黄芪是我国传统的治疗心血管疾病的中药。然而，其机制尚未完全了解。本研究通过体外实验和饮食诱导的动脉粥样硬化家兔模型，探讨黄芪总黄酮（TFA）对心血管疾病的保护作用及其机制。我们确定了六个组成部分和它们在TFA中的比例。动物实验表明，TFA能显著降低血浆总胆固醇和低密度脂蛋白胆固醇（P < 0.05 ~ 0.01），升高高密度脂蛋白胆固醇（P < 0.01），并使主动脉脂肪纹面积减少43.6 ~ 63.6%（P < 0.01）。我们还发现，TFA清除超氧阴离子和羟基自由基，这种效果与较高的TFA浓度增加。在体实验中，TFA有效地抑制了缺血再灌注模型中的自由基谱。总之，反式脂肪酸是黄芪的活性成分，它有益于心血管疾病归因于有效的抗氧化活性，以改善动脉粥样硬化概况。
Astragalus mongholicus Bunge has long been used to treat cardiovascular disease in Chinese traditional medicine. However, its mechanisms are not fully understood. In this study, we explored potential mechanisms and protective effects of total flavonoids of Astragalus (TFA) on cardiovascular disease using in vitro experiments and diet-induced atherosclerotic rabbits. We identified six components and their proportion in TFA. The animal experiments showed that TFA significantly reduced plasma levels of total cholesterol and LDL cholesterol (P < 0.05 to 0.01), increased HDL cholesterol levels (P < 0.01), and reduced the aortic fatty streak area by 43.6 to 63.6% (P < 0.01). We also found that TFA scavenged superoxide and hydroxyl radicals and this effect increased with higher TFA concentration. In in vivo experiments, TFA effectively inhibited the free radical spectrum in the ischemia-reperfusion module. In conclusion, TFA was the active component of Astragalus mongholicus Bunge, which benefits cardiovascular disease attributing to the potent antioxidant activity to improve the atherosclerosis profile.
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影响因子：
2.4
作者：
Graf, BA;Milbury, PE;Blumberg, JB
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