Functional network structure supports resilience to memory deficits in cognitively normal older adults with amyloid-β pathology.
Functional network structure supports resilience to memory deficits in cognitively normal older adults with amyloid-β pathology.
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DOI：
10.1038/s41598-023-40092-x
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发表时间：
2023-08-25
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
老年人可能患有大量的淀粉样蛋白-β（Aβ）病理，但在记忆评估中仍处于年龄正常水平。我们测试了功能性脑网络是否赋予弹性或补偿机制，以支持面对Aβ病理学的记忆。65名认知正常的老年人接受了高分辨率静息状态fMRI评估功能网络，18F-florbetapir-PET测量Aβ和记忆评估。我们用局部效率（信息传递），模块化（功能模块的专业化）和小世界性（集成和隔离的平衡）的图形度量来表征功能网络。高Aβ（Aβ+）老年人与无/低Aβ（Aβ−）老年人之间的功能网络测量值无差异。然而，在Aβ+老年人中，局部效率、模块性和小世界性的增加与更好的记忆表现相关，而这种关系在Aβ-老年人中没有发生。此外，Aβ+老年人的局部效率增加和记忆表现更好之间的关联局限于默认模式网络和海马体的局部效率，这些区域易受Aβ影响并参与记忆处理。我们的研究结果表明，具有模块化和有效结构的功能网络与Aβ病理学的弹性相关，为干预提供了功能靶点。
Older adults may harbor large amounts of amyloid-β (Aβ) pathology, yet still perform at age-normal levels on memory assessments. We tested whether functional brain networks confer resilience or compensatory mechanisms to support memory in the face of Aβ pathology. Sixty-five cognitively normal older adults received high-resolution resting state fMRI to assess functional networks, 18F-florbetapir-PET to measure Aβ, and a memory assessment. We characterized functional networks with graph metrics of local efficiency (information transfer), modularity (specialization of functional modules), and small worldness (balance of integration and segregation). There was no difference in functional network measures between older adults with high Aβ (Aβ+) compared to those with no/low Aβ (Aβ−). However, in Aβ+ older adults, increased local efficiency, modularity, and small worldness were associated with better memory performance, while this relationship did not occur Aβ− older adults. Further, the association between increased local efficiency and better memory performance in Aβ+ older adults was localized to local efficiency of the default mode network and hippocampus, regions vulnerable to Aβ and involved in memory processing. Our results suggest functional networks with modular and efficient structures are associated with resilience to Aβ pathology, providing a functional target for intervention.
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影响因子：
16.6
作者：
通讯作者：
--
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
人脑网络组图谱：基于连接架构的新大脑图谱
DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Fan L;Li H;Zhuo J;Zhang Y;Wang J;Chen L;Yang Z;Chu C;Xie S;Laird AR;Fox PT;Eickhoff SB;Yu C;Jiang T
通讯作者：
Jiang T
影响因子：
7.7
作者：
Adams, Jenna N.;Maass, Anne;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
14.5
作者：
Ewers, Michael;Luan, Ying;Franzmeier, Nicolai
通讯作者：
Franzmeier, Nicolai