Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance.
Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance.
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疟原虫感染中单核细胞和巨噬细胞 Tim-3 的下调及其与寄生虫清除的关系
DOI：
10.3389/fmicb.2017.01431
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发表时间：
2017
影响因子：
5.2
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Hou N;Jiang N;Zou Y;Piao X;Liu S;Li S;Chen Q
T细胞免疫球蛋白和含粘蛋白结构域的分子3（Tim-3）在多种疾病中调节单核细胞和巨噬细胞方面发挥着复杂的作用，并且它往往是一种抑制性分子，促进疟疾寄生虫的免疫逃逸。然而，Tim-3 介导疟疾中单核细胞和巨噬细胞反应的机制尚不清楚。在这项研究中，我们发现疟原虫感染下调了恶性疟原虫疟疾患者外周单核细胞和伯氏疟原虫 ANKA 感染小鼠脾脏巨噬细胞中 Tim-3 的表达。使用抗 Tim-3 抗体阻断 Tim-3 信号可增强疟原虫感染期间小鼠脾巨噬细胞的吞噬作用和寄生介质的产生。总之，Tim-3 会限制单核细胞/巨噬细胞的活性，而抗 Tim-3 治疗有利于寄生虫的清除，尤其是在疟原虫感染的早期阶段。
T-cell immunoglobulin and mucin-domain-containing molecule 3 (Tim-3) has complicated roles in regulating monocytes and macrophages in various diseases and it tends to be an inhibitory molecule to facilitate the immune escape of parasites in malaria. However, the mechanisms of Tim-3 mediated responses in monocytes and macrophages in malaria have not been clear. In this study, we found that Plasmodium infection down-regulated Tim-3 expression in peripheral monocytes of patients suffering from Plasmodium falciparum malaria and in splenic macrophages of Plasmodium berghei ANKA-infected mice. Tim-3 signal blockade with anti-Tim-3 antibodies enhanced phagocytosis and parasitical mediator production of murine splenic macrophages during Plasmodium infection. In conclusion, Tim-3 constricts monocytes/macrophages activity, and anti-Tim-3 treatment facilitates parasite clearance, especially in the early stage of Plasmodium infection.
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影响因子：
16.8
作者：
Sakuishi K;Jayaraman P;Behar SM;Anderson AC;Kuchroo VK
通讯作者：
Kuchroo VK
影响因子：
6.4
作者：
Costa, Pedro A. C.;Leoratti, Fabiana M. S.;Antonelli, Lis R. V.
通讯作者：
Antonelli, Lis R. V.
影响因子：
6.4
作者：
Carvalho, Bruna O.;Lopes, Stefanie C. P.;Costa, Fabio T. M.
通讯作者：
Costa, Fabio T. M.
影响因子：
30.5
作者：
Sabatos, CA;Chakravarti, S;Kuchroo, VK
通讯作者：
Kuchroo, VK
Galectin-9与TIM-3的CIS缔合通过TLR信号传导在单核细胞中调节IL-12/IL-23的表达。
影响因子：
3.7
作者：
Ma CJ;Li GY;Cheng YQ;Wang JM;Ying RS;Shi L;Wu XY;Niki T;Hirashima M;Li CF;Moorman JP;Yao ZQ
通讯作者：
Yao ZQ