Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis.
Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis.
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DOI：
10.1007/s00125-010-1874-x
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发表时间：
2010-12
期刊：
影响因子：
8.2
通讯作者：
Pouwer, F.
中科院分区：
文献类型：
--
作者：
Nouwen, A.;Winkley, K.;Twisk, J.;Lloyd, C. E.;Peyrot, M.;Ismail, K.;Pouwer, F.
早期的荟萃分析表明，糖尿病是抑郁症发展和/或复发的危险因素。然而，使用问卷调查的研究与那些依赖抑郁症诊断标准的研究是否存在这种风险还没有得到检验。本研究通过回顾文献和对有关这一主题的纵向研究进行荟萃分析，探讨了糖尿病与抑郁症发病的关系。检索EMBASE、MEDLINE和PsycInfo中截至2009年9月发表的文章。所有研究2型糖尿病和抑郁症发病之间的关系都包括在内。使用固定和随机效应模型计算合并相对风险。11项研究符合我们的纳入标准。基于合并数据，包括48，808例基线时无抑郁的2型糖尿病病例，随机效应模型的合并相对风险为1.24（95%CI 1.09-1.40）。依赖抑郁症诊断标准的研究比使用问卷调查的研究的风险明显更高。然而，当控制出版年份时，这种差异不再显著。与非糖尿病对照组相比，2型糖尿病患者患抑郁症的风险增加了24%。这种关系背后的机制尚不清楚，需要进一步研究。本文的在线版本（doi：10.1007/s 00125 -010-1874-x）包含补充材料，可供授权用户使用。
An earlier meta-analysis showed that diabetes is a risk factor for the development and/or recurrence of depression. Yet whether this risk is different for studies using questionnaires than for those relying on diagnostic criteria for depression has not been examined. This study examined the association of diabetes and the onset of depression by reviewing the literature and conducting a meta-analysis of longitudinal studies on this topic. EMBASE, MEDLINE and PsycInfo were searched for articles published up to September 2009. All studies that examined the relationship between type 2 diabetes and the onset of depression were included. Pooled relative risks were calculated using fixed and random effects models. Eleven studies met our inclusion criteria for this meta-analysis. Based on the pooled data, including 48,808 cases of type 2 diabetes without depression at baseline, the pooled relative risk was 1.24 (95% CI 1.09–1.40) for the random effects model. This risk was significantly higher for studies relying on diagnostic criteria of depression than for studies using questionnaires. However, this difference was no longer significant when controlled for year of publication. Compared with non-diabetic controls, people with type 2 diabetes have a 24% increased risk of developing depression. The mechanisms underlying this relationship are still unclear and warrant further research. The online version of this article (doi:10.1007/s00125-010-1874-x) contains supplementary material, which is available to authorised users.
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